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Effect of a Dual Orexin Receptor Antagonist, Lemborexant, on Total Sleep Time in Shift Workers: a Randomized Controlled Trial

The UCSF Shift Study is a double-blind placebo-controlled clinical trial investigating the effect of Lemborexant as a daytime sleep aid in shift workers. Lemborexant, an FDA approved insomnia medication, is a hypocretin/orexin antagonist. For this reason, we are interested in whether this medicine will be effective in helping shift workers sleep during the day. This study is broken into two parts: a 3-week placebo-controlled treatment phase and an optional 2-week open-label phase. We are currently hoping to enroll night-shift workers for this study. 


The Brain Health Registry: Understanding the Experiences of Family Caregivers

If you are 18 years or over, you can help the Brain Health Registry speed up the discovery of treatments for Alzheimer’s, Parkinson’s, depression, PTSD, and other brain disorders. It takes just a few minutes to get started. For most people, participation takes less than three hours per year. The steps are easy to follow:

  1. Sign up
    Sign up by clicking here! Tell us who you are, how we can reach you, and electronically sign an informed consent form. That’s all it takes to get you enrolled as a participant.
  2. Tell us about yourself
    Answer a set of questionnaires about your medical history, current health and lifestyle. Each takes just a few minutes — and you don’t have to do them all in one sitting! You can stop and start whenever you like. 
  3. Take some tests
    Take some online brain tests. These tests are like games and they only take a few minutes to complete.
  4. Invite a study partner
    Ask a friend, family member, or spouse to join the Brain Health Registry as your study partner. Study partners answer questions that help us gain a more complete understanding of brain health, including information about your brain health, day-to-day functioning and quality of life. If your study partner is a caregiver to you, they will also be able to answer questions about their experience as a caregiver.
  5. Come back… and come back again!
    We'd like you to come back every 3-6 months to answer more questions and take more tests. Don’t worry about remembering — we’ll send you an email to remind you when it's time to come back! Our hope is that you will continue to participate over the course of many years. That’s what will really help researchers to understand the human brain as it ages and changes.

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