Allison Xu, PhD

Diabetes Center
+1 415 476-2807

Neuronal modulation of hepatic lipid accumulation induced by binge-like drinking.

American journal of physiology. Endocrinology and metabolism

Ibars M, Maier MT, Yulyaningsih E, Perez L, Cheang R, Vilhelmsson A, Louie SM, Wegner SA, Yuan X, Eltzschig HK, Hopf FW, Nomura DK, Koliwad SK, Xu AW

Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.


Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW

Hypothalamic Sensing of Bile Acids, a Gut Feeling.

Trends in endocrinology and metabolism: TEM


Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.

Cell reports

Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW

Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis.

International journal of molecular sciences

Wu CS, Bongmba OYN, Yue J, Lee JH, Lin L, Saito K, Pradhan G, Li DP, Pan HL, Xu A, Guo S, Xu Y, Sun Y

Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice.

Alcoholism, clinical and experimental research

Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW

Leptin potentiates astrogenesis in the developing hypothalamus.

Molecular metabolism

Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW

Hypothalamic inflammation in the control of metabolic function.

Annual review of physiology

Valdearcos M, Xu AW, Koliwad SK

An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females.

Cell reports

Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA

Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

Cell reports

Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK

Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Warne JP, Varonin JM, Nielsen SS, Olofsson LE, Kaelin CB, Chua S, Barsh GS, Koliwad SK, Xu AW

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance.

Proceedings of the National Academy of Sciences of the United States of America

Olofsson LE, Unger EK, Cheung CC, Xu AW

Metabolic transceivers: in tune with the central melanocortin system.

Trends in endocrinology and metabolism: TEM

Warne JP, Xu AW

AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice.


Newton AJ, Hess S, Paeger L, Vogt MC, Fleming Lascano J, Nillni EA, Brüning JC, Kloppenburg P, Xu AW

Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity.

Cell metabolism

Warne JP, Alemi F, Reed AS, Varonin JM, Chan H, Piper ML, Mullin ME, Myers MG, Corvera CU, Xu AW

Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Dietrich MO, Antunes C, Geliang G, Liu ZW, Borok E, Nie Y, Xu AW, Souza DO, Gao Q, Diano S, Gao XB, Horvath TL

De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Pierce AA, Xu AW

Functional role of c-Jun-N-terminal kinase in feeding regulation.


Unger EK, Piper ML, Olofsson LE, Xu AW

Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice.

Developmental biology

Su H, Marcheva B, Meng S, Liang FA, Kohsaka A, Kobayashi Y, Xu AW, Bass J, Wang X

Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake.

Proceedings of the National Academy of Sciences of the United States of America

Olofsson LE, Pierce AA, Xu AW

Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.


van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG, Schwartz GJ, Chua SC

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

The Journal of clinical investigation

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ

Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid.

Molecular endocrinology (Baltimore, Md.)

Kaelin CB, Gong L, Xu AW, Yao F, Hockman K, Morton GJ, Schwartz MW, Barsh GS, MacKenzie RG

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake.

Nature medicine

Kitamura T, Feng Y, Kitamura YI, Chua SC, Xu AW, Barsh GS, Rossetti L, Accili D

MC4R neurons weigh in differently.

Nature neuroscience

Xu AW, Barsh GS

Effects of hypothalamic neurodegeneration on energy balance.

PLoS biology

Xu AW, Kaelin CB, Morton GJ, Ogimoto K, Stanhope K, Graham J, Baskin DG, Havel P, Schwartz MW, Barsh GS

Agouti-related peptide-expressing neurons are mandatory for feeding.

Nature neuroscience

Gropp E, Shanabrough M, Borok E, Xu AW, Janoschek R, Buch T, Plum L, Balthasar N, Hampel B, Waisman A, Barsh GS, Horvath TL, Brüning JC

GCN5 and p300 share essential functions during early embryogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists

Phan HM, Xu AW, Coco C, Srajer G, Wyszomierski S, Evrard YA, Eckner R, Dent SY

The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

The Journal of clinical investigation

Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ

PI3K integrates the action of insulin and leptin on hypothalamic neurons.

The Journal of clinical investigation

Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS