Frederick Hecht, MD

Professor
Medicine
+1 415 475-4082

I am trained in Internal Medicine, with additional training in clinical research methods, biostatistics, and behavioral medicine. My research focus for many years was on HIV. I developed one of the largest cohorts in the world of persons followed from primary HIV (within 6 months of infection), the Options Project, in which we have examined clinical, behavioral, cardiovascular, and immunologic research questions. In 2002, I became Director of Research at the UCSF Osher Center for Integrative Medicine. My research is driven by the belief that modern medicine has made impressive advances in treating a range of health conditions, but that further advances for many of the most important health problems of our era, including obesity, diabetes, heart disease, and mental health issues require improved development and implementation of lifestyle and other non-pharmacologic approaches. An important goal of my research program is to rigorously test whether we can improve interventions for chronic health problems such as HIV, diabetes, obesity, and stress, by incorporating mindfulness and/or yoga-based components. A current example is an NIH-funded study to test whether including training in mindful eating practices decreases eating in response to food cravings and enhances adherence to a nutritional plan in type 2 diabetes.

In my role as Director of the UCSF Osher Center Research Program, I have played a key leadership role in building it into an internationally recognized integrative medicine research center that is distinguished by the application of innovative and rigorous research designs to studying mindfulness-based interventions, yoga, acupuncture, interoceptive awareness, and behavioral interventions. I served in a variety of leadership roles in HIV medicine and integrative medicine, including as chair of the Organizing Committee of the 2016 International Congress on Integrative Medicine and Health, which gives me a broad view of the field. I have a strong commitment to mentoring. I have led UCSF’s highly successful Training Research in Integrative Medicine (TRIM) fellowship program since 2006, and have served as a primary or main co-mentor on 11 K awards. I have served as PI or co-PI/project director for 29 grants, 17 of them from NIH, including leading three Program Project grants.

Publications: 

Frequency of Post Treatment Control Varies by ART Restart and Viral Load Criteria.

AIDS (London, England)

Fajnzylber J, Sharaf R, Hutchinson JN, Aga E, Bosch RJ, Hartogensis W, Jacobson JM, Connick E, Volberding P, Skiest DJ, Margolis D, Sneller MC, Little SJ, Gulick RM, Mellors JW, Gandhi RT, Schooley RT, Henry K, Tebas P, Deeks S, Chun TW, Collier AC, Hecht FM, Li JZ, CHAMP study team

Cell-associated HIV RNA has a Circadian Cycle in Males Living with HIV on Antiretroviral Therapy.

The Journal of infectious diseases

Stern J, Solomon A, Dantanarayana A, Pascoe R, Reynaldi A, Davenport MP, Milush J, Deeks SG, Hartogensis W, Hecht FM, Cockerham L, Roche M, Lewin SR

Methods-Motivational Interviewing Approach for Enhanced Retention and Attendance.

American journal of preventive medicine

Jake-Schoffman DE, Brown SD, Baiocchi M, Bibeau JL, Daubenmier J, Ferrara A, Galarce MN, Hartogensis W, Hecht FM, Hedderson MM, Moran PJ, Pagoto SL, Tsai AL, Waring ME, Kiernan M

Alternative Dietary Patterns for Americans: Low-Carbohydrate Diets.

Nutrients

Volek JS, Phinney SD, Krauss RM, Johnson RJ, Saslow LR, Gower B, Yancy WS, King JC, Hecht FM, Teicholz N, Bistrian BR, Hamdy O

HIV-1 Genomes Are Enriched in Memory CD4+ T-Cells with Short Half-Lives.

mBio

Morcilla V, Bacchus-Souffan C, Fisher K, Horsburgh BA, Hiener B, Wang XQ, Schlub TE, Fitch M, Hoh R, Hecht FM, Martin JN, Deeks SG, Hellerstein MK, McCune JM, Hunt PW, Palmer S

Exploratory Analysis of Racial/Ethnic and Educational Differences in a Randomized Controlled Trial of a Mindfulness-based Weight Loss Intervention.

Psychosomatic medicine

Daubenmier J, Chao MT, Hartogensis W, Liu R, Moran PJ, Acree MC, Kristeller J, Epel ES, Hecht FM

Cellular activation, differentiation and proliferation influence the dynamics of genetically-intact proviruses over time.

The Journal of infectious diseases

Horsburgh BA, Hiener B, Fisher K, Lee E, Morgan H, Eden JS, von Stockenstrom S, Odevall L, Milush JM, Hoh R, Fromentin R, Chomont N, Hecht FM, Schlub TE, Deeks SG, Palmer S

Some But Not All Biomarkers of Immune Activation Remain Abnormal Despite Very Early Treatment of HIV.

The Journal of infectious diseases

Schnittman SR, Deitchman AN, Beck-Engeser G, Ahn H, York VA, Hartig H, Hecht FM, Martin JN, Deeks SG, Aweeka FT, Hunt PW

Complex wavelet filter improves FLIM phasors for photon starved imaging experiments.

Biomedical optics express

Wang P, Hecht F, Ossato G, Tille S, Fraser SE, Junge JA

Enhanced Stress Resilience Training in Surgeons: Iterative Adaptation and Biopsychosocial Effects in 2 Small Randomized Trials.

Annals of surgery

Lebares CC, Coaston TN, Delucchi KL, Guvva EV, Shen WT, Staffaroni AM, Kramer JH, Epel ES, Hecht FM, Ascher NL, Harris HW, Cole SW

TCF-1 regulates HIV-specific CD8+ T cell expansion capacity.

JCI insight

Rutishauser RL, Deguit CDT, Hiatt J, Blaeschke F, Roth TL, Wang L, Raymond KA, Starke CE, Mudd JC, Chen W, Smullin CP, Matus-Nicodemos R, Hoh R, Krone MR, Hecht FM, Pilcher CD, Martin JN, Koup RA, Douek DC, Brenchley JM, Sékaly RP, Pillai SK, Marson A, Deeks SG, McCune JM, Hunt PW

Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART.

PLoS pathogens

Bacchus-Souffan C, Fitch M, Symons J, Abdel-Mohsen M, Reeves DB, Hoh R, Stone M, Hiatt J, Kim P, Chopra A, Ahn H, York VA, Cameron DL, Hecht FM, Martin JN, Yukl SA, Mallal S, Cameron PU, Deeks SG, Schiffer JT, Lewin SR, Hellerstein MK, McCune JM, Hunt PW

Corrigendum: Toward a Compassionate Intersectional Neuroscience: Increasing Diversity and Equity in Contemplative Neuroscience.

Frontiers in psychology

Weng HY, Ikeda MP, Lewis-Peacock JA, Chao MT, Fullwiley D, Goldman V, Skinner S, Duncan LG, Gazzaley A, Hecht FM

Feasibility of continuous fever monitoring using wearable devices.

Scientific reports

Smarr BL, Aschbacher K, Fisher SM, Chowdhary A, Dilchert S, Puldon K, Rao A, Hecht FM, Mason AE

A 4-Month Whole-Systems Ayurvedic Medicine Nutrition and Lifestyle Intervention Is Feasible and Acceptable for Breast Cancer Survivors: Results of a Single-Arm Pilot Clinical Trial.

Global advances in health and medicine

Dhruva A, Wu C, Miaskowski C, Hartogensis W, Rugo HS, Adler SR, Kaptchuk TJ, Kelkar R, Agarawal S, Vadodaria A, Garris E, Hecht FM

Toward a Compassionate Intersectional Neuroscience: Increasing Diversity and Equity in Contemplative Neuroscience.

Frontiers in psychology

Weng HY, Ikeda MP, Lewis-Peacock JA, Chao MT, Fullwiley D, Goldman V, Skinner S, Duncan LG, Gazzaley A, Hecht FM

Can We Agree What Skilled Mindfulness-Based Teaching Looks Like? Lessons From Studying the MBI:TAC.

Global advances in health and medicine

S Crane R, Hecht FM, Brewer J, Griffith GM, Hartogensis W, Koerbel L, Moran P, Sansom S, Yiangou A, Kuyken W

Intervention Enhancement Strategies Among Adults With Type 2 Diabetes in a Very Low-Carbohydrate Web-Based Program: Evaluating the Impact With a Randomized Trial.

JMIR diabetes

Saslow LR, Moskowitz JT, Mason AE, Daubenmier J, Liestenfeltz B, Missel AL, Bayandorian H, Aikens JE, Kim S, Hecht FM

Focus on the Breath: Brain Decoding Reveals Internal States of Attention During Meditation.

Frontiers in human neuroscience

Weng HY, Lewis-Peacock JA, Hecht FM, Uncapher MR, Ziegler DA, Farb NAS, Goldman V, Skinner S, Duncan LG, Chao MT, Gazzaley A

Delayed expression of PD1 and TIGIT on HIV-specific CD8 T-cells in untreated HLA-B*57:01 individuals followed from early infection.

Journal of virology

Scharf L, Tauriainen J, Buggert M, Hartogensis W, Nolan DJ, Deeks SG, Salemi M, Hecht FM, Karlsson AC

Longitudinal study reveals HIV-1-infected CD4+ T cell dynamics during long-term antiretroviral therapy.

The Journal of clinical investigation

Antar AAR, Jenike KM, Jang S, Rigau DN, Reeves DB, Hoh R, Krone MR, Keruly JC, Moore RD, Schiffer JT, Nonyane BA, Hecht FM, Deeks SG, Siliciano JD, Ho YC, Siliciano RF

Semen virome of men with HIV on or off antiretroviral treatment.

AIDS (London, England)

Li Y, Altan E, Pilcher C, Hartogensis W, Hecht FM, Deng X, Delwart E

High levels of genetically-intact HIV in HLA-DR+ memory T-cells indicates their value for reservoir studies.

AIDS (London, England)

Horsburgh BA, Lee E, Hiener B, Eden JS, Schlub TE, von Stockenstrom S, Odevall L, Milush JM, Liegler T, Sinclair E, Hoh R, Boritz EA, Douek DC, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S

Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy.

The Journal of infectious diseases

Anderson JL, Khoury G, Fromentin R, Solomon A, Chomont N, Sinclair E, Milush JM, Hartogensis W, Bacchetti P, Roche M, Tumpach C, Gartner M, Pitman MC, Epling CL, Hoh R, Hecht FM, Somsouk M, Cameron PU, Deeks SG, Lewin SR

The impact of antiretroviral therapy duration on the HIV-1 infection of T-cells within anatomic sites.

Journal of virology

Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S

Correction: Examining the Effects of Mindful Eating Training on Adherence to a Carbohydrate-Restricted Diet in Patients With Type 2 Diabetes (the DELISH Study): Protocol for a Randomized Controlled Trial.

JMIR research protocols

Mason AE, Saslow L, Moran PJ, Kim S, Wali PK, Abousleiman H, Hartman A, Richler R, Schleicher S, Hartogensis W, Epel ES, Hecht F

Correction to: Lipid findings from the Diabetes Education to Lower Insulin, Sugars, and Hunger (DELISH) Study.

Nutrition & metabolism

Mason AE, Saslow LR, Moran PJ, Kim S, Wali PK, Abousleiman H, Richler R, Schleicher S, Goldman VM, Hartman A, Leung C, Hartogensis W, Hecht FM

Ketogenic Diets for Diabetes and Obesity.

JAMA internal medicine

Hecht FM

Do stress eating or compulsive eating influence metabolic health in a mindfulness-based weight loss intervention?

Health psychology : official journal of the Division of Health Psychology, American Psychological Association

Radin RM, Epel ES, Daubenmier J, Moran P, Schleicher S, Kristeller J, Hecht FM, Mason AE

A Randomized Clinical Trial of Group Acupuncture for Painful Diabetic Neuropathy Among Diverse Safety Net Patients.

Pain medicine (Malden, Mass.)

Chao MT, Schillinger D, Nguyen U, Santana T, Liu R, Gregorich S, Hecht FM

Effects of a Mindfulness-Based Intervention on Distress, Weight Gain, and Glucose Control for Pregnant Low-Income Women: A Quasi-Experimental Trial Using the ORBIT Model.

International journal of behavioral medicine

Epel E, Laraia B, Coleman-Phox K, Leung C, Vieten C, Mellin L, Kristeller JL, Thomas M, Stotland N, Bush N, Lustig RH, Dallman M, Hecht FM, Adler N

Acupressure and Therapeutic Touch in Childhood Cancer to Promote Subjective and Intersubjective Experiences of Well-being During Curative Treatment.

Global advances in health and medicine

Hu H, Shear D, Thakkar R, Thompson-Lastad A, Pinderhughes H, Hecht FM, Lown EA

Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy.

Frontiers in microbiology

Lee E, Bacchetti P, Milush J, Shao W, Boritz E, Douek D, Fromentin R, Liegler T, Hoh R, Deeks SG, Hecht FM, Chomont N, Palmer S

A Randomized Controlled Trial of a Mindfulness-Based Weight Loss Intervention on Cardiovascular Reactivity to Social-Evaluative Threat Among Adults with Obesity.

Mindfulness

Daubenmier J, Epel ES, Moran PJ, Thompson J, Mason AE, Acree M, Goldman V, Kristeller J, Hecht FM, Mendes WB

Lipid findings from the Diabetes Education to Lower Insulin, Sugars, and Hunger (DELISH) Study.

Nutrition & metabolism

Mason AE, Saslow LR, Moran PJ, Kim S, Abousleiman H, Richler R, Schleicher S, Goldman VM, Hartman A, Leung C, Hartogensis W, Hecht FM

Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial.

Global advances in health and medicine

Lown EA, Banerjee A, Vittinghoff E, Dvorak CC, Hartogensis W, Melton A, Mangurian C, Hu H, Shear D, Adcock R, Morgan M, Golden C, Hecht FM

Examining the Effects of Mindful Eating Training on Adherence to a Carbohydrate-Restricted Diet in Type 2 Diabetes: the DELISH Study Protocol.

JMIR research protocols

Mason AE, Saslow L, Moran PJ, Kim S, Abousleiman H, Hartman A, Richler R, Schleicher S, Hartogensis W, Epel ES, Hecht F

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.

Nature communications

Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ, Lewin SR, Routy JP, Sékaly RP, Chomont N

The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies.

The Journal of infectious diseases

Namazi G, Fajnzylber JM, Aga E, Bosch RJ, Acosta EP, Sharaf R, Hartogensis W, Jacobson JM, Connick E, Volberding P, Skiest D, Margolis D, Sneller MC, Little SJ, Gianella S, Smith DM, Kuritzkes DR, Gulick RM, Mellors JW, Mehraj V, Gandhi RT, Mitsuyasu R, Schooley RT, Henry K, Tebas P, Deeks SG, Chun TW, Collier AC, Routy JP, Hecht FM, Walker BD, Li JZ

Variation in cell-associated unspliced HIV RNA on antiretroviral therapy is associated with the circadian regulator brain-and-muscle-ARNT-like-1.

AIDS (London, England)

Chang CC, Naranbhai V, Stern J, Roche M, Dantanarayana A, Ke R, Tennakoon S, Solomon A, Hoh R, Hartogensis W, Hecht FM, Sikaris K, Price DJ, Elliott JH, Deeks SG, Churchill M, Cameron PU, Hengartner N, Perelson AS, Lewin SR

Burnout and gender in surgical training: A call to re-evaluate coping and dysfunction.

American journal of surgery

Lebares CC, Braun HJ, Guvva EV, Epel ES, Hecht FM

Weight loss, weight-loss maintenance, and cellular aging in the Supporting Health through Nutrition and Exercise (SHINE) Study.

Psychosomatic medicine

Mason AE, Hecht FM, Daubenmier JJ, Sbarra DA, Lin J, Moran PJ, Schleicher SG, Acree M, Prather AA, Epel ES

A Randomized, Controlled Trial of Mindfulness-Based Stress Reduction in HIV Infection.

Brain, behavior, and immunity

Hecht FM, Moskowitz JT, Moran P, Epel ES, Bacchetti P, Acree M, Kemeny ME, Mendes WB, Duncan LG, Weng H, Levy JA, Deeks SG, Folkman S

Increasing Physical Activity in Mothers Using Video Exercise Groups and Exercise Mobile Apps: Randomized Controlled Trial.

Journal of medical Internet research

Mascarenhas MN, Chan JM, Vittinghoff E, Van Blarigan EL, Hecht F

Novel Interventions to Reduce Stress and Overeating in Overweight Pregnant Women: A Feasibility Study.

Maternal and child health journal

Laraia BA, Adler NE, Coleman-Phox K, Vieten C, Mellin L, Kristeller JL, Thomas M, Stotland NE, Lustig RH, Dallman MF, Hecht FM, Bush NR, de Groat CL, Epel E

Positive and Negative Self-Conscious Emotion and Transmission Risk Following HIV Diagnosis.

AIDS and behavior

Batchelder AW, Carrico AW, Acree M, Hecht FM, Moskowitz JT

Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection.

Journal of immunology (Baltimore, Md. : 1950)

Kiniry BE, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL

Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes.

Nutrition & diabetes

Saslow LR, Daubenmier JJ, Moskowitz JT, Kim S, Murphy EJ, Phinney SD, Ploutz-Snyder R, Goldman V, Cox RM, Mason AE, Moran P, Hecht FM

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants.

Cell reports

Hiener B, Horsburgh BA, Eden JS, Barton K, Schlub TE, Lee E, von Stockenstrom S, Odevall L, Milush JM, Liegler T, Sinclair E, Hoh R, Boritz EA, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S

Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers.

Retrovirology

de Mulder M, SenGupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon DF, Michaud HA

Enriched environment and stress exposure influence splenic B lymphocyte composition.

PloS one

Gurfein BT, Hasdemir B, Milush JM, Touma C, Palme R, Nixon DF, Darcel N, Hecht FM, Bhargava A

HIV Antibody Level as a Marker of HIV Persistence and Low-Level Viral Replication.

The Journal of infectious diseases

Keating SM, Pilcher CD, Jain V, Lebedeva M, Hampton D, Abdel-Mohsen M, Deng X, Murphy G, Welte A, Facente SN, Hecht F, Deeks SG, Pillai SK, Busch MP

Improving Assessment of the Spectrum of Reward-Related Eating: The RED-13.

Frontiers in psychology

Mason AE, Vainik U, Acree M, Tomiyama AJ, Dagher A, Epel ES, Hecht FM

Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression.

AIDS research and human retroviruses

Rutishauser RL, Hartogensis W, Deguit CD, Krone M, Hoh R, Hecht FM, Pilcher CD, Bacchetti P, Deeks SG, Hunt PW, McCune JM

A humanized mouse-based HIV-1 viral outgrowth assay with higher sensitivity than in vitro qVOA in detecting latently infected cells from individuals on ART with undetectable viral loads.

Virology

Charlins P, Schmitt K, Remling-Mulder L, Hogan LE, Hanhauser E, Hobbs KS, Hecht F, Deeks SG, Henrich TJ, Akkina R

Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus-Infected Individuals Receiving Suppressive Antiretroviral Therapy.

The Journal of infectious diseases

Khoury G, Fromentin R, Solomon A, Hartogensis W, Killian M, Hoh R, Somsouk M, Hunt PW, Girling V, Sinclair E, Bacchetti P, Anderson JL, Hecht FM, Deeks SG, Cameron PU, Chomont N, Lewin SR

An Online Intervention Comparing a Very Low-Carbohydrate Ketogenic Diet and Lifestyle Recommendations Versus a Plate Method Diet in Overweight Individuals With Type 2 Diabetes: A Randomized Controlled Trial.

Journal of medical Internet research

Saslow LR, Mason AE, Kim S, Goldman V, Ploutz-Snyder R, Bayandorian H, Daubenmier J, Hecht FM, Moskowitz JT

Comprehensive and Medically Appropriate Food Support Is Associated with Improved HIV and Diabetes Health.

Journal of urban health : bulletin of the New York Academy of Medicine

Palar K, Napoles T, Hufstedler LL, Seligman H, Hecht FM, Madsen K, Ryle M, Pitchford S, Frongillo EA, Weiser SD

Feasibility and Preliminary Efficacy of a Novel RDoC-Based Treatment Program for Adolescent Depression: "Training for Awareness Resilience and Action" (TARA)-A Pilot Study.

Frontiers in psychiatry

Henje Blom E, Tymofiyeva O, Chesney MA, Ho TC, Moran P, Connolly CG, Duncan LG, Baldini L, Weng HY, Acree M, Goldman V, Hecht FM, Yang TT

Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.

Scientific reports

Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren HG, Sönnerborg A, Lund O, Reyes-Terán G, Hecht FM, Deeks SG, Betts MR, Buggert M, Karlsson AC

Impact of a Mindfulness-Based Weight-Loss Intervention on Sleep Quality Among Adults with Obesity: Data from the SHINE Randomized Controlled Trial.

Journal of alternative and complementary medicine (New York, N.Y.)

Adler E, Dhruva A, Moran PJ, Daubenmier J, Acree M, Epel ES, Bacchetti P, Prather AA, Mason A, Hecht FM

Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size.

Journal of virology

Pinzone MR, Graf E, Lynch L, McLaughlin B, Hecht FM, Connors M, Migueles SA, Hwang WT, Nunnari G, O'Doherty U

Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection.

Mucosal immunology

Kiniry BE, Ganesh A, Critchfield JW, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL

Psoriasis risk SNPs and their association with HIV-1 control.

Human immunology

Nititham J, Gupta R, Zeng X, Hartogensis W, Nixon DF, Deeks SG, Hecht FM, Liao W

Viral load criteria and threshold optimization to improve HIV incidence assay characteristics.

AIDS (London, England)

Kassanjee R, Pilcher CD, Busch MP, Murphy G, Facente SN, Keating SM, Mckinney E, Marson K, Price MA, Martin JN, Little SJ, Hecht FM, Kallas EG, Welte A

Correction: Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes.

PloS one

Willberg CB, Garrison KE, Jones RB, Meiklejohn DA, Spotts G, Liegler TJ, Ostrowski MA, Karlsson AC, Hecht FM, Nixon DF

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.

PLoS pathogens

Fromentin R, Bakeman W, Lawani MB, Khoury G, Hartogensis W, DaFonseca S, Killian M, Epling L, Hoh R, Sinclair E, Hecht FM, Bacchetti P, Deeks SG, Lewin SR, Sékaly RP, Chomont N

Immunologic profiles distinguish aviremic HIV-infected adults.

AIDS (London, England)

Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, McCune JM, Deeks SG, Hunt PW

Persistence of integrated HIV DNA in CXCR3?+?CCR6?+?memory CD4+ T cells in HIV-infected individuals on antiretroviral therapy.

AIDS (London, England)

Khoury G, Anderson JL, Fromentin R, Hartogenesis W, Smith MZ, Bacchetti P, Hecht FM, Chomont N, Cameron PU, Deeks SG, Lewin SR

Adjunctive acupuncture for pain and symptom management in the inpatient setting: protocol for a pilot hybrid effectiveness-implementation study.

Journal of integrative medicine

Chao MT, Chang A, Reddy S, Harrison JD, Acquah J, Toveg M, Santana T, Hecht FM

Effects of a mindfulness-based weight loss intervention in adults with obesity: A randomized clinical trial.

Obesity (Silver Spring, Md.)

Daubenmier J, Moran PJ, Kristeller J, Acree M, Bacchetti P, Kemeny ME, Dallman M, Lustig RH, Grunfeld C, Nixon DF, Milush JM, Goldman V, Laraia B, Laugero KD, Woodhouse L, Epel ES, Hecht FM

Reduced reward-driven eating accounts for the impact of a mindfulness-based diet and exercise intervention on weight loss: Data from the SHINE randomized controlled trial.

Appetite

Mason AE, Epel ES, Aschbacher K, Lustig RH, Acree M, Kristeller J, Cohn M, Dallman M, Moran PJ, Bacchetti P, Laraia B, Hecht FM, Daubenmier J

Factors related to telomere length.

Brain, behavior, and immunity

Prather AA, Hecht FM, Epel ES

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.

PLoS pathogens

Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC

Nausea is associated with endotoxemia during a 161-km ultramarathon.

Journal of sports sciences

Stuempfle KJ, Valentino T, Hew-Butler T, Hecht FM, Hoffman MD

Effects of a mindfulness-based intervention on mindful eating, sweets consumption, and fasting glucose levels in obese adults: data from the SHINE randomized controlled trial.

Journal of behavioral medicine

Mason AE, Epel ES, Kristeller J, Moran PJ, Dallman M, Lustig RH, Acree M, Bacchetti P, Laraia BA, Hecht FM, Daubenmier J

Efficient Identification of HIV Serodiscordant Couples by Existing HIV Testing Programs in South Brazil.

PloS one

Pilcher CD, Bisol CA, Paganella MP, Vallabhaneni S, da Motta LR, Kato SK, Sperhacke RD, Kallas EG, Hecht FM, Diaz RS

Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.

Cell reports

Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y, Apetrei C, Pandrea I, Hecht FM, Pilcher CD, Klatt NR, Brenchley JM, Lynch SV, McCune JM

Experiences with food insecurity and risky sex among low-income people living with HIV/AIDS in a resource-rich setting.

Journal of the International AIDS Society

Whittle HJ, Palar K, Napoles T, Hufstedler LL, Ching I, Hecht FM, Frongillo EA, Weiser SD

Dispositional Mindfulness in People with HIV: Associations with Psychological and Physical Health.

Personality and individual differences

Moskowitz JT, Duncan LG, Moran PJ, Acree M, Epel ES, Kemeny ME, Hecht FM, Folkman S

Training in ChiRunning to reduce blood pressure: a randomized controlled pilot study.

BMC complementary and alternative medicine

McDermott K, Kumar D, Goldman V, Feng H, Mehling W, Moskowitz JT, Souza RB, Hecht FM

Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor.

Proceedings of the National Academy of Sciences of the United States of America

Gornalusse GG, Mummidi S, Gaitan AA, Jimenez F, Ramsuran V, Picton A, Rogers K, Manoharan MS, Avadhanam N, Murthy KK, Martinez H, Molano Murillo A, Chykarenko ZA, Hutt R, Daskalakis D, Shostakovich-Koretskaya L, Abdool Karim S, Martin JN, Deeks SG, Hecht F, Sinclair E, Clark RA, Okulicz J, Valentine FT, Martinson N, Tiemessen CT, Ndung'u T, Hunt PW, He W, Ahuja SK

Putting the brakes on the "drive to eat": Pilot effects of naltrexone and reward-based eating on food cravings among obese women.

Eating behaviors

Mason AE, Laraia B, Daubenmier J, Hecht FM, Lustig RH, Puterman E, Adler N, Dallman M, Kiernan M, Gearhardt AN, Epel ES

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals.

EBioMedicine

Procopio FA, Fromentin R, Kulpa DA, Brehm JH, Bebin AG, Strain MC, Richman DD, O'Doherty U, Palmer S, Hecht FM, Hoh R, Barnard RJ, Miller MD, Hazuda DJ, Deeks SG, Sékaly RP, Chomont N

Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences.

PloS one

Eriksson EM, Liegler T, Keh CE, Karlsson AC, Holditch SJ, Pilcher CD, Loeb L, Nixon DF, Hecht FM

Acute responses to opioidergic blockade as a biomarker of hedonic eating among obese women enrolled in a mindfulness-based weight loss intervention trial.

Appetite

Mason AE, Lustig RH, Brown RR, Acree M, Bacchetti P, Moran PJ, Dallman M, Laraia B, Adler N, Hecht FM, Daubenmier J, Epel ES

Clinical decision rule for primary care patient with acute low back pain at risk of developing chronic pain.

The spine journal : official journal of the North American Spine Society

Mehling WE, Ebell MH, Avins AL, Hecht FM

Can a back pain screening tool help classify patients with acute pain into risk levels for chronic pain?

European journal of pain (London, England)

Mehling WE, Avins AL, Acree MC, Carey TS, Hecht FM

Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy.

The Journal of infectious diseases

von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, Boritz E, Deeks SG, Hecht FM, Palmer S

Select host restriction factors are associated with HIV persistence during antiretroviral therapy.

AIDS (London, England)

Abdel-Mohsen M, Wang C, Strain MC, Lada SM, Deng X, Cockerham LR, Pilcher CD, Hecht FM, Liegler T, Richman DD, Deeks SG, Pillai SK

Effects of Form-Focused Training on Running Biomechanics: A Pilot Randomized Trial in Untrained Individuals.

PM & R : the journal of injury, function, and rehabilitation

Kumar D, McDermott K, Feng H, Goldman V, Luke A, Souza RB, Hecht FM

Deep sequencing of HIV-1 variants from paired plasma and cerebrospinal fluid during primary HIV infection.

Journal of virus eradication

Gega A, Kozal MJ, Chiarella J, Lee E, Peterson J, Hecht FM, Liegler T, St John EP, Simen BB, Price RW, Spudich SS

High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men-San Francisco, California.

The Journal of infectious diseases

Hollingsworth TD, Pilcher CD, Hecht FM, Deeks SG, Fraser C

Tired telomeres: Poor global sleep quality, perceived stress, and telomere length in immune cell subsets in obese men and women.

Brain, behavior, and immunity

Prather AA, Gurfein B, Moran P, Daubenmier J, Acree M, Bacchetti P, Sinclair E, Lin J, Blackburn E, Hecht FM, Epel ES

CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells.

PloS one

Cockerham LR, Siliciano JD, Sinclair E, O'Doherty U, Palmer S, Yukl SA, Strain MC, Chomont N, Hecht FM, Siliciano RF, Richman DD, Deeks SG

Independent assessment of candidate HIV incidence assays on specimens in the CEPHIA repository.

AIDS (London, England)

Kassanjee R, Pilcher CD, Keating SM, Facente SN, McKinney E, Price MA, Martin JN, Little S, Hecht FM, Kallas EG, Welte A, Busch MP, Murphy G

Baseline CD4+ T cell counts correlates with HIV-1 synonymous rate in HLA-B*5701 subjects with different risk of disease progression.

PLoS computational biology

Norström MM, Veras NM, Huang W, Proper MC, Cook J, Hartogensis W, Hecht FM, Karlsson AC, Karlsoon AC, Salemi M

Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.

PLoS pathogens

Klatt NR, Bosinger SE, Peck M, Richert-Spuhler LE, Heigele A, Gile JP, Patel N, Taaffe J, Julg B, Camerini D, Torti C, Martin JN, Deeks SG, Sinclair E, Hecht FM, Lederman MM, Paiardini M, Kirchhoff F, Brenchley JM, Hunt PW, Silvestri G

Emergence of individual HIV-specific CD8 T cell responses during primary HIV-1 infection can determine long-term disease outcome.

Journal of virology

Streeck H, Lu R, Beckwith N, Milazzo M, Liu M, Routy JP, Little S, Jessen H, Kelleher AD, Hecht F, Sekaly RP, Alter G, Heckerman D, Carrington M, Rosenberg ES, Altfeld M

The development of an RDoC-based treatment program for adolescent depression: "Training for Awareness, Resilience, and Action" (TARA).

Frontiers in human neuroscience

Henje Blom E, Duncan LG, Ho TC, Connolly CG, LeWinn KZ, Chesney M, Hecht FM, Yang TT

Programmed death-1 expression on CD4? and CD8? T cells in treated and untreated HIV disease.

AIDS (London, England)

Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG

Dynamic regulation of host restriction factor expression over the course of HIV-1 infection in vivo.

Journal of virology

Raposo RA, Abdel-Mohsen M, Deng X, Hecht FM, Pilcher CD, Pillai SK, Nixon DF

A yoga intervention for type 2 diabetes risk reduction: a pilot randomized controlled trial.

BMC complementary and alternative medicine

McDermott KA, Rao MR, Nagarathna R, Murphy EJ, Burke A, Nagendra RH, Hecht FM

Decreased HIV type 1 transcription in CCR5-?32 heterozygotes during suppressive antiretroviral therapy.

The Journal of infectious diseases

Wang C, Abdel-Mohsen M, Strain MC, Lada SM, Yukl S, Cockerham LR, Pilcher CD, Hecht FM, Sinclair E, Liegler T, Richman DD, Deeks SG, Pillai SK

Longitudinal characterization of depression and mood states beginning in primary HIV infection.

AIDS and behavior

Gold JA, Grill M, Peterson J, Pilcher C, Lee E, Hecht FM, Fuchs D, Yiannoutsos CT, Price RW, Robertson K, Spudich S

HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.

PLoS pathogens

Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG

Environmental enrichment alters splenic immune cell composition and enhances secondary influenza vaccine responses in mice.

Molecular medicine (Cambridge, Mass.)

Gurfein BT, Davidenko O, Premenko-Lanier M, Milush JM, Acree M, Dallman MF, Touma C, Palme R, York VA, Fromentin G, Darcel N, Nixon DF, Hecht FM

Functional avidity and IL-2/perforin production is linked to the emergence of mutations within HLA-B*5701-restricted epitopes and HIV-1 disease progression.

Journal of immunology (Baltimore, Md. : 1950)

Buggert M, Norström MM, Salemi M, Hecht FM, Karlsson AC

Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection.

The Journal of infectious diseases

Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW

Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging.

PloS one

Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW

Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection.

Retrovirology

Michaud HA, de Mulder M, SenGupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon DF

CD56negCD16? NK cells are activated mature NK cells with impaired effector function during HIV-1 infection.

Retrovirology

Milush JM, López-Vergès S, York VA, Deeks SG, Martin JN, Hecht FM, Lanier LL, Nixon DF

Correlating traditional Ayurvedic and modern medical perspectives on cancer: results of a qualitative study.

Journal of alternative and complementary medicine (New York, N.Y.)

Dhruva A, Hecht FM, Miaskowski C, Kaptchuk TJ, Bodeker G, Abrams D, Lad V, Adler SR

Performance of rapid point-of-care and laboratory tests for acute and established HIV infection in San Francisco.

PloS one

Pilcher CD, Louie B, Facente S, Keating S, Hackett J, Vallari A, Hall C, Dowling T, Busch MP, Klausner JD, Hecht FM, Liska S, Pandori MW

A new biomarker of hedonic eating? A preliminary investigation of cortisol and nausea responses to acute opioid blockade.

Appetite

Daubenmier J, Lustig RH, Hecht FM, Kristeller J, Woolley J, Adam T, Dallman M, Epel E

The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.

Proceedings of the National Academy of Sciences of the United States of America

Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S

Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection.

Retrovirology

Vaidya SA, Streeck H, Beckwith N, Ghebremichael M, Pereyra F, Kwon DS, Addo MM, Rychert J, Routy JP, Jessen H, Kelleher AD, Hecht F, Sekaly RP, Carrington M, Walker BD, Allen TM, Rosenberg ES, Altfeld M

HIV-1 Vif adaptation to human APOBEC3H haplotypes.

Cell host & microbe

Ooms M, Brayton B, Letko M, Maio SM, Pilcher CD, Hecht FM, Barbour JD, Simon V

Cortisol patterns are associated with T cell activation in HIV.

PloS one

Patterson S, Moran P, Epel E, Sinclair E, Kemeny ME, Deeks SG, Bacchetti P, Acree M, Epling L, Kirschbaum C, Hecht FM

Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size.

The Journal of infectious diseases

Jain V, Hartogensis W, Bacchetti P, Hunt PW, Hatano H, Sinclair E, Epling L, Lee TH, Busch MP, McCune JM, Pilcher CD, Hecht FM, Deeks SG

T cells target APOBEC3 proteins in human immunodeficiency virus type 1-infected humans and simian immunodeficiency virus-infected Indian rhesus macaques.

Journal of virology

Champiat S, Garrison KE, Raposo RA, Burwitz BJ, Reed J, Tandon R, York VA, Newman LP, Nimityongskul FA, Wilson NA, Almeida RR, Martin JN, Deeks SG, Rosenberg MG, Wiznia AA, Spotts GE, Pilcher CD, Hecht FM, Ostrowski MA, Sacha JB, Nixon DF

Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.

PLoS pathogens

Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD

Changes in seroadaptive practices from before to after diagnosis of recent HIV infection among men who have sex with men.

PloS one

Vallabhaneni S, McConnell JJ, Loeb L, Hartogensis W, Hecht FM, Grant RM, Pilcher CD

Targeting of conserved gag-epitopes in early HIV infection is associated with lower plasma viral load and slower CD4(+) T cell depletion.

AIDS research and human retroviruses

Perez CL, Milush JM, Buggert M, Eriksson EM, Larsen MV, Liegler T, Hartogensis W, Bacchetti P, Lund O, Hecht FM, Nixon DF, Karlsson AC

Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells.

The Journal of infectious diseases

Hatano H, Jain V, Hunt PW, Lee TH, Sinclair E, Do TD, Hoh R, Martin JN, McCune JM, Hecht F, Busch MP, Deeks SG

Combination of immune and viral factors distinguishes low-risk versus high-risk HIV-1 disease progression in HLA-B*5701 subjects.

Journal of virology

Norström MM, Buggert M, Tauriainen J, Hartogensis W, Prosperi MC, Wallet MA, Hecht FM, Salemi M, Karlsson AC

Influence of HAART on alternative reading frame immune responses over the course of HIV-1 infection.

PloS one

Champiat S, Raposo RA, Maness NJ, Lehman JL, Purtell SE, Hasenkrug AM, Miller JC, Dean H, Koff WC, Hong MA, Martin JN, Deeks SG, Spotts GE, Pilcher CD, Hecht FM, Kallas EG, Garrison KE, Nixon DF

The association of CD4+ T-cell counts and cardiovascular risk in treated HIV disease.

AIDS (London, England)

Ho JE, Scherzer R, Hecht FM, Maka K, Selby V, Martin JN, Ganz P, Deeks SG, Hsue PY

The calm mouse: an animal model of stress reduction.

Molecular medicine (Cambridge, Mass.)

Gurfein BT, Stamm AW, Bacchetti P, Dallman MF, Nadkarni NA, Milush JM, Touma C, Palme R, Di Borgo CP, Fromentin G, Lown-Hecht R, Konsman JP, Acree M, Premenko-Lanier M, Darcel N, Hecht FM, Nixon DF

Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA.

The Journal of infectious diseases

Josefsson L, Eriksson S, Sinclair E, Ho T, Killian M, Epling L, Shao W, Lewis B, Bacchetti P, Loeb L, Custer J, Poole L, Hecht FM, Palmer S

Yoga breathing for cancer chemotherapy-associated symptoms and quality of life: results of a pilot randomized controlled trial.

Journal of alternative and complementary medicine (New York, N.Y.)

Dhruva A, Miaskowski C, Abrams D, Acree M, Cooper B, Goodman S, Hecht FM

The prognosis of acute low back pain in primary care in the United States: a 2-year prospective cohort study.

Spine

Mehling WE, Gopisetty V, Bartmess E, Acree M, Pressman A, Goldberg H, Hecht FM, Carey T, Avins AL

Hematopoietic cell transplant and use of massage for improved symptom management: results from a pilot randomized control trial.

Evidence-based complementary and alternative medicine : eCAM

Mehling WE, Lown EA, Dvorak CC, Cowan MJ, Horn BN, Dunn EA, Acree M, Abrams DI, Hecht FM

Acute low back pain and primary care: how to define recovery and chronification?

Spine

Mehling WE, Gopisetty V, Acree M, Pressman A, Carey T, Goldberg H, Hecht FM, Avins AL

Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study.

Psychoneuroendocrinology

Daubenmier J, Lin J, Blackburn E, Hecht FM, Kristeller J, Maninger N, Kuwata M, Bacchetti P, Havel PJ, Epel E

Expansion of CD8+ T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacity.

Blood

Eriksson EM, Milush JM, Ho EL, Batista MD, Holditch SJ, Keh CE, Norris PJ, Keating SM, Deeks SG, Hunt PW, Martin JN, Rosenberg MG, Hecht FM, Nixon DF

Mindfulness Intervention for Stress Eating to Reduce Cortisol and Abdominal Fat among Overweight and Obese Women: An Exploratory Randomized Controlled Study.

Journal of obesity

Daubenmier J, Kristeller J, Hecht FM, Maninger N, Kuwata M, Jhaveri K, Lustig RH, Kemeny M, Karan L, Epel E

HIV-1 infection abrogates CD8+ T cell mitogen-activated protein kinase signaling responses.

Journal of virology

Crawford TQ, Ndhlovu LC, Tan A, Carvidi A, Hecht FM, Sinclair E, Barbour JD

Mindfulness-based stress reduction for HIV treatment side effects: a randomized, wait-list controlled trial.

Journal of pain and symptom management

Duncan LG, Moskowitz JT, Neilands TB, Dilworth SE, Hecht FM, Johnson MO

Central nervous system immune activation characterizes primary human immunodeficiency virus 1 infection even in participants with minimal cerebrospinal fluid viral burden.

The Journal of infectious diseases

Spudich S, Gisslen M, Hagberg L, Lee E, Liegler T, Brew B, Fuchs D, Tambussi G, Cinque P, Hecht FM, Price RW

Identifying the early post-HIV antibody seroconversion period.

The Journal of infectious diseases

Hecht FM, Wellman R, Busch MP, Pilcher CD, Norris PJ, Margolick JB, Collier AC, Little SJ, Markowitz M, Routy JP, Holte S

Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection.

Journal of virology

SenGupta D, Tandon R, Vieira RG, Ndhlovu LC, Lown-Hecht R, Ormsby CE, Loh L, Jones RB, Garrison KE, Martin JN, York VA, Spotts G, Reyes-Terán G, Ostrowski MA, Hecht FM, Deeks SG, Nixon DF

Differential persistence of transmitted HIV-1 drug resistance mutation classes.

The Journal of infectious diseases

Jain V, Sucupira MC, Bacchetti P, Hartogensis W, Diaz RS, Kallas EG, Janini LM, Liegler T, Pilcher CD, Grant RM, Cortes R, Deeks SG, Hecht FM

NK cells and CD1d-restricted NKT cells respond in different ways with divergent kinetics to IL-2 treatment in primary HIV-1 infection.

Scandinavian journal of immunology

Kuylenstierna C, Snyder-Cappione JE, Loo CP, Long BR, Gonzalez VD, Michaëlsson J, Moll M, Spotts G, Hecht FM, Nixon DF, Sandberg JK

HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells.

Blood

Favre D, Stoddart CA, Emu B, Hoh R, Martin JN, Hecht FM, Deeks SG, McCune JM

APOBEC3H haplotypes and HIV-1 pro-viral vif DNA sequence diversity in early untreated human immunodeficiency virus-1 infection.

Human immunology

Gourraud PA, Karaouni A, Woo JM, Schmidt T, Oksenberg JR, Hecht FM, Liegler TJ, Barbour JD

Transmitted drug resistance in persons with acute/early HIV-1 in San Francisco, 2002-2009.

PloS one

Jain V, Liegler T, Vittinghoff E, Hartogensis W, Bacchetti P, Poole L, Loeb L, Pilcher CD, Grant RM, Deeks SG, Hecht FM

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Science (New York, N.Y.)

Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PI, Walker BD, Ripke S, Brumme CJ, Pulit SL, Carrington M, Kadie CM, Carlson JM, Heckerman D, Graham RR, Plenge RM, Deeks SG, Gianniny L, Crawford G, Sullivan J, Gonzalez E, Davies L, Camargo A, Moore JM, Beattie N, Gupta S, Crenshaw A, Burtt NP, Guiducci C, Gupta N, Gao X, Qi Y, Yuki Y, Piechocka-Trocha A, Cutrell E, Rosenberg R, Moss KL, Lemay P, O'Leary J, Schaefer T, Verma P, Toth I, Block B, Baker B, Rothchild A, Lian J, Proudfoot J, Alvino DM, Vine S, Addo MM, Allen TM, Altfeld M, Henn MR, Le Gall S, Streeck H, Haas DW, Kuritzkes DR, Robbins GK, Shafer RW, Gulick RM, Shikuma CM, Haubrich R, Riddler S, Sax PE, Daar ES, Ribaudo HJ, Agan B, Agarwal S, Ahern RL, Allen BL, Altidor S, Altschuler EL, Ambardar S, Anastos K, Anderson B, Anderson V, Andrady U, Antoniskis D, Bangsberg D, Barbaro D, Barrie W, Bartczak J, Barton S, Basden P, Basgoz N, Bazner S, Bellos NC, Benson AM, Berger J, Bernard NF, Bernard AM, Birch C, Bodner SJ, Bolan RK, Boudreaux ET, Bradley M, Braun JF, Brndjar JE, Brown SJ, Brown K, Brown ST, Burack J, Bush LM, Cafaro V, Campbell O, Campbell J, Carlson RH, Carmichael JK, Casey KK, Cavacuiti C, Celestin G, Chambers ST, Chez N, Chirch LM, Cimoch PJ, Cohen D, Cohn LE, Conway B, Cooper DA, Cornelson B, Cox DT, Cristofano MV, Cuchural G, Czartoski JL, Dahman JM, Daly JS, Davis BT, Davis K, Davod SM, DeJesus E, Dietz CA, Dunham E, Dunn ME, Ellerin TB, Eron JJ, Fangman JJ, Farel CE, Ferlazzo H, Fidler S, Fleenor-Ford A, Frankel R, Freedberg KA, French NK, Fuchs JD, Fuller JD, Gaberman J, Gallant JE, Gandhi RT, Garcia E, Garmon D, Gathe JC, Gaultier CR, Gebre W, Gilman FD, Gilson I, Goepfert PA, Gottlieb MS, Goulston C, Groger RK, Gurley TD, Haber S, Hardwicke R, Hardy WD, Harrigan PR, Hawkins TN, Heath S, Hecht FM, Henry WK, Hladek M, Hoffman RP, Horton JM, Hsu RK, Huhn GD, Hunt P, Hupert MJ, Illeman ML, Jaeger H, Jellinger RM, John M, Johnson JA, Johnson KL, Johnson H, Johnson K, Joly J, Jordan WC, Kauffman CA, Khanlou H, Killian RK, Kim AY, Kim DD, Kinder CA, Kirchner JT, Kogelman L, Kojic EM, Korthuis PT, Kurisu W, Kwon DS, LaMar M, Lampiris H, Lanzafame M, Lederman MM, Lee DM, Lee JM, Lee MJ, Lee ET, Lemoine J, Levy JA, Llibre JM, Liguori MA, Little SJ, Liu AY, Lopez AJ, Loutfy MR, Loy D, Mohammed DY, Man A, Mansour MK, Marconi VC, Markowitz M, Marques R, Martin JN, Martin HL, Mayer KH, McElrath MJ, McGhee TA, McGovern BH, McGowan K, McIntyre D, Mcleod GX, Menezes P, Mesa G, Metroka CE, Meyer-Olson D, Miller AO, Montgomery K, Mounzer KC, Nagami EH, Nagin I, Nahass RG, Nelson MO, Nielsen C, Norene DL, O'Connor DH, Ojikutu BO, Okulicz J, Oladehin OO, Oldfield EC, Olender SA, Ostrowski M, Owen WF, Pae E, Parsonnet J, Pavlatos AM, Perlmutter AM, Pierce MN, Pincus JM, Pisani L, Price LJ, Proia L, Prokesch RC, Pujet HC, Ramgopal M, Rathod A, Rausch M, Ravishankar J, Rhame FS, Richards CS, Richman DD, Rodes B, Rodriguez M, Rose RC, Rosenberg ES, Rosenthal D, Ross PE, Rubin DS, Rumbaugh E, Saenz L, Salvaggio MR, Sanchez WC, Sanjana VM, Santiago S, Schmidt W, Schuitemaker H, Sestak PM, Shalit P, Shay W, Shirvani VN, Silebi VI, Sizemore JM, Skolnik PR, Sokol-Anderson M, Sosman JM, Stabile P, Stapleton JT, Starrett S, Stein F, Stellbrink HJ, Sterman FL, Stone VE, Stone DR, Tambussi G, Taplitz RA, Tedaldi EM, Telenti A, Theisen W, Torres R, Tosiello L, Tremblay C, Tribble MA, Trinh PD, Tsao A, Ueda P, Vaccaro A, Valadas E, Vanig TJ, Vecino I, Vega VM, Veikley W, Wade BH, Walworth C, Wanidworanun C, Ward DJ, Warner DA, Weber RD, Webster D, Weis S, Wheeler DA, White DJ, Wilkins E, Winston A, Wlodaver CG, van't Wout A, Wright DP, Yang OO, Yurdin DL, Zabukovic BW, Zachary KC, Zeeman B, Zhao M

Acute HIV-1 infection: what's new? Where are we going?

The Journal of infectious diseases

D'Souza MP, Axten KL, Hecht FM, Altfeld M

The detection of acute HIV infection.

The Journal of infectious diseases

Cohen MS, Gay CL, Busch MP, Hecht FM

IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the periphery.

Journal of clinical immunology

Ndhlovu LC, Sinclair E, Epling L, Tan QX, Ho T, Jha AR, Eccles-James I, Tincati C, Levy JA, Nixon DF, Hecht FM, Barbour JD

Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.

Science translational medicine

Favre D, Mold J, Hunt PW, Kanwar B, Loke P, Seu L, Barbour JD, Lowe MM, Jayawardene A, Aweeka F, Huang Y, Douek DC, Brenchley JM, Martin JN, Hecht FM, Deeks SG, McCune JM

The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection.

The Journal of infectious diseases

Markowitz M, Vaida F, Hare CB, Boden D, Mohri H, Hecht FM, Kalayjian RC, Conrad A, Mildvan D, Aberg J, Hogan C, Kilby JM, Balfour HH, Schafer K, Richman D, Little S

HIV RNA level in early infection is predicted by viral load in the transmission source.

AIDS (London, England)

Hecht FM, Hartogensis W, Bragg L, Bacchetti P, Atchison R, Grant R, Barbour J, Deeks SG

Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes.

PloS one

Willberg CB, Garrison KE, Jones RB, Meiklejohn DA, Spotts G, Liegler TJ, Ostrowski MA, Karlsson AC, Hecht FM, Nixon DF

Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease.

PloS one

Naeger DM, Martin JN, Sinclair E, Hunt PW, Bangsberg DR, Hecht F, Hsue P, McCune JM, Deeks SG

Immune escape mutations detected within HIV-1 epitopes associated with viral control during treatment interruption.

Journal of acquired immune deficiency syndromes (1999)

Schweighardt B, Wrin T, Meiklejohn DA, Spotts G, Petropoulos CJ, Nixon DF, Hecht FM

HIV-Selectest enzyme immunoassay and rapid test: ability to detect seroconversion following HIV-1 infection.

Journal of clinical microbiology

Khurana S, Norris PJ, Busch MP, Haynes BF, Park S, Sasono P, Mlisana K, Salim AK, Hecht FM, Mulenga J, Chomba E, Hunter E, Allen S, Nemo G, Rodriguez-Chavez IR, Margolick JB, Golding H

Lower cytokine secretion ex vivo by natural killer T cells in HIV-infected individuals is associated with higher CD161 expression.

AIDS (London, England)

Snyder-Cappione JE, Loo CP, Carvalho KI, Kuylenstierna C, Deeks SG, Hecht FM, Rosenberg MG, Sandberg JK, Kallas EG, Nixon DF

Characterization of human immunodeficiency virus type 1 populations containing CXCR4-using variants from recently infected individuals.

AIDS research and human retroviruses

Huang W, Toma J, Stawiski E, Fransen S, Wrin T, Parkin N, Whitcomb JM, Coakley E, Hecht FM, Deeks SG, Gandhi RT, Eshleman SH, Petropoulos CJ

Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responses.

Clinical and vaccine immunology : CVI

Garrison KE, Champiat S, York VA, Agrawal AT, Kallas EG, Martin JN, Hecht FM, Deeks SG, Nixon DF

Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells.

Journal of virology

Streeck H, Jolin JS, Qi Y, Yassine-Diab B, Johnson RC, Kwon DS, Addo MM, Brumme C, Routy JP, Little S, Jessen HK, Kelleher AD, Hecht FM, Sekaly RP, Rosenberg ES, Walker BD, Carrington M, Altfeld M

Body awareness: construct and self-report measures.

PloS one

Mehling WE, Gopisetty V, Daubenmier J, Price CJ, Hecht FM, Stewart A

Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Kelley CF, Kitchen CM, Hunt PW, Rodriguez B, Hecht FM, Kitahata M, Crane HM, Willig J, Mugavero M, Saag M, Martin JN, Deeks SG

Tolerability and efficacy of PI versus NNRTI-based regimens in subjects receiving HAART during acute or early HIV infection.

Journal of acquired immune deficiency syndromes (1999)

Apuzzo LG, Vaida F, Gallant JE, Ernstrom KB, Little SJ, Routy JP, Collier AC, Conway B, Markowitz MH, Hecht FM, Walker BD, Connick E, Margolick JB

High CD8+ T cell activation marks a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression of viral replication.

PloS one

Barbour JD, Ndhlovu LC, Xuan Tan Q, Ho T, Epling L, Bredt BM, Levy JA, Hecht FM, Sinclair E

CD8+ cell anti-HIV activity rapidly increases upon discontinuation of early antiretroviral therapy.

Journal of clinical immunology

Killian MS, Roop J, Ng S, Hecht FM, Levy JA

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.

The Journal of experimental medicine

Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, Wong JC, Satkunarajah M, Schweneker M, Chapman JM, Gyenes G, Vali B, Hyrcza MD, Yue FY, Kovacs C, Sassi A, Loutfy M, Halpenny R, Persad D, Spotts G, Hecht FM, Chun TW, McCune JM, Kaul R, Rini JM, Nixon DF, Ostrowski MA

Immunity to HIV-1 is influenced by continued natural exposure to exogenous virus.

PLoS pathogens

Willberg CB, McConnell JJ, Eriksson EM, Bragg LA, York VA, Liegler TJ, Hecht FM, Grant RM, Nixon DF

Prevalence of oral disease among adults with primary HIV infection.

Oral diseases

Owotade FJ, Shiboski CH, Poole L, Ramstead CA, Malvin K, Hecht FM, Greenspan JS

Stimulant use is associated with immune activation and depleted tryptophan among HIV-positive persons on anti-retroviral therapy.

Brain, behavior, and immunity

Carrico AW, Johnson MO, Morin SF, Remien RH, Riley ED, Hecht FM, Fuchs D

Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance.

AIDS (London, England)

Liu L, May S, Richman DD, Hecht FM, Markowitz M, Daar ES, Routy JP, Margolick JB, Collier AC, Woelk CH, Little SJ, Smith DM

CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals.

Nature medicine

Ahuja SK, Kulkarni H, Catano G, Agan BK, Camargo JF, He W, O'Connell RJ, Marconi VC, Delmar J, Eron J, Clark RA, Frost S, Martin J, Ahuja SS, Deeks SG, Little S, Richman D, Hecht FM, Dolan MJ

Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection.

Journal of virology

Long BR, Ndhlovu LC, Oksenberg JR, Lanier LL, Hecht FM, Nixon DF, Barbour JD

Assessment of rapid tests for detection of human immunodeficiency virus-specific antibodies in recently infected individuals.

Journal of clinical microbiology

Louie B, Wong E, Klausner JD, Liska S, Hecht F, Dowling T, Obeso M, Phillips SS, Pandori MW

Clinical presentation and diagnosis of primary HIV-1 infection.

Current opinion in HIV and AIDS

Daar ES, Pilcher CD, Hecht FM

Immune reconstitution of CD56(dim) NK cells in individuals with primary HIV-1 infection treated with interleukin-2.

The Journal of infectious diseases

Michaëlsson J, Long BR, Loo CP, Lanier LL, Spotts G, Hecht FM, Nixon DF

Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virus.

Clinical and vaccine immunology : CVI

Long BR, Michaelsson J, Loo CP, Ballan WM, Vu BA, Hecht FM, Lanier LL, Chapman JM, Nixon DF

T cell responses to human endogenous retroviruses in HIV-1 infection.

PLoS pathogens

Garrison KE, Jones RB, Meiklejohn DA, Anwar N, Ndhlovu LC, Chapman JM, Erickson AL, Agrawal A, Spotts G, Hecht FM, Rakoff-Nahoum S, Lenz J, Ostrowski MA, Nixon DF

CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms.

Nature immunology

Dolan MJ, Kulkarni H, Camargo JF, He W, Smith A, Anaya JM, Miura T, Hecht FM, Mamtani M, Pereyra F, Marconi V, Mangano A, Sen L, Bologna R, Clark RA, Anderson SA, Delmar J, O'Connell RJ, Lloyd A, Martin J, Ahuja SS, Agan BK, Walker BD, Deeks SG, Ahuja SK

Loss of T cell responses following long-term cryopreservation.

Journal of immunological methods

Owen RE, Sinclair E, Emu B, Heitman JW, Hirschkorn DF, Epling CL, Tan QX, Custer B, Harris JM, Jacobson MA, McCune JM, Martin JN, Hecht FM, Deeks SG, Norris PJ

The relation between symptoms, viral load, and viral load set point in primary HIV infection.

Journal of acquired immune deficiency syndromes (1999)

Kelley CF, Barbour JD, Hecht FM

Frequent detection of the parvoviruses, PARV4 and PARV5, in plasma from blood donors and symptomatic individuals.

Transfusion

Fryer JF, Delwart E, Hecht FM, Bernardin F, Jones MS, Shah N, Baylis SA

Quantitative longitudinal analysis of T cell receptor repertoire expression in HIV-infected patients on antiretroviral and interleukin-2 therapy.

AIDS research and human retroviruses

Sriram U, Wong M, Caillier SJ, Hecht FM, Elkins MK, Levy JA, Oksenberg JR, Baranzini SE

Lessons from an HIV transmission pair.

The Journal of infectious diseases

Hecht FM, Wolf LE, Lo B

Symptom management with massage and acupuncture in postoperative cancer patients: a randomized controlled trial.

Journal of pain and symptom management

Mehling WE, Jacobs B, Acree M, Wilson L, Bostrom A, West J, Acquah J, Burns B, Chapman J, Hecht FM

Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape.

PloS one

Karlsson AC, Iversen AK, Chapman JM, de Oliviera T, Spotts G, McMichael AJ, Davenport MP, Hecht FM, Nixon DF

Lessons from primary HIV infection.

Focus (San Francisco, Calif.)

Hecht F, Pilcher C

Frequent methamphetamine use is associated with primary non-nucleoside reverse transcriptase inhibitor resistance.

AIDS (London, England)

Colfax GN, Vittinghoff E, Grant R, Lum P, Spotts G, Hecht FM

Microbial translocation is a cause of systemic immune activation in chronic HIV infection.

Nature medicine

Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D, Blazar BR, Rodriguez B, Teixeira-Johnson L, Landay A, Martin JN, Hecht FM, Picker LJ, Lederman MM, Deeks SG, Douek DC

Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity.

AIDS (London, England)

Barbour JD, Hecht FM, Little SJ, Markowitz M, Daar ES, Kelleher AD, Routy JP, Campbell TB, Rosenberg ES, Segal MR, Weidler J, Grant RM

Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo.

Journal of virology

Zimmerman ES, Sherman MP, Blackett JL, Neidleman JA, Kreis C, Mundt P, Williams SA, Warmerdam M, Kahn J, Hecht FM, Grant RM, de Noronha CM, Weyrich AS, Greene WC, Planelles V

A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection.

The Journal of infectious diseases

Hecht FM, Wang L, Collier A, Little S, Markowitz M, Margolick J, Kilby JM, Daar E, Conway B, Holte S

Elevations in IL-10, TNF-alpha, and IFN-gamma from the earliest point of HIV Type 1 infection.

AIDS research and human retroviruses

Norris PJ, Pappalardo BL, Custer B, Spotts G, Hecht FM, Busch MP

The effects of early antiretroviral therapy and its discontinuation on the HIV-specific antibody response.

AIDS research and human retroviruses

Killian MS, Norris PJ, Rawal BD, Lebedeva M, Hecht FM, Levy JA, Busch MP

Newly diagnosed HIV infection.

The New England journal of medicine

Chin-Hong PV, Hecht FM, Klausner JD

Seroreversion in subjects receiving antiretroviral therapy during acute/early HIV infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Hare CB, Pappalardo BL, Busch MP, Karlsson AC, Phelps BH, Alexander SS, Bentsen C, Ramstead CA, Nixon DF, Levy JA, Hecht FM

Expansion of CD1d-restricted NKT cells in patients with primary HIV-1 infection treated with interleukin-2.

Blood

Moll M, Snyder-Cappione J, Spotts G, Hecht FM, Sandberg JK, Nixon DF

Seroconversion following nonoccupational postexposure prophylaxis against HIV.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Roland ME, Neilands TB, Krone MR, Katz MH, Franses K, Grant RM, Busch MP, Hecht FM, Shacklett BL, Kahn JO, Bamberger JD, Coates TJ, Chesney MA, Martin JN

Potential herpesvirus interaction during HIV type 1 primary infection.

AIDS research and human retroviruses

Lennette ET, Busch MP, Hecht FM, Levy JA

Resistance testing in drug-naive HIV-infected patients: is it time?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Hecht FM, Grant RM

New DNA viruses identified in patients with acute viral infection syndrome.

Journal of virology

Jones MS, Kapoor A, Lukashov VV, Simmonds P, Hecht F, Delwart E

Randomized, controlled trial of breath therapy for patients with chronic low-back pain.

Alternative therapies in health and medicine

Mehling WE, Hamel KA, Acree M, Byl N, Hecht FM

Bias control in trials of bodywork: a review of methodological issues.

Journal of alternative and complementary medicine (New York, N.Y.)

Mehling WE, DiBlasi Z, Hecht F

Longitudinal analysis of B cell repertoire and antibody gene rearrangements during early HIV infection.

Genes and immunity

Elkins MK, Vittinghoff E, Baranzini SE, Hecht FM, Sriram U, Busch MP, Levy JA, Oksenberg JR

Interleukin-2 therapy restores CD8 cell non-cytotoxic anti-HIV responses in primary infection subjects receiving HAART.

AIDS (London, England)

Martinez-Mariño B, Shiboski S, Hecht FM, Kahn JO, Levy JA

Persistence of primary drug resistance among recently HIV-1 infected adults.

AIDS (London, England)

Barbour JD, Hecht FM, Wrin T, Liegler TJ, Ramstead CA, Busch MP, Segal MR, Petropoulos CJ, Grant RM

Expansion of CD7(low) and CD7(negative) CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment.

Blood

Aandahl EM, Quigley MF, Moretto WJ, Moll M, Gonzalez VD, Sönnerborg A, Lindbäck S, Hecht FM, Deeks SG, Rosenberg MG, Nixon DF, Sandberg JK

Higher CD4+ T cell counts associated with low viral pol replication capacity among treatment-naive adults in early HIV-1 infection.

The Journal of infectious diseases

Barbour JD, Hecht FM, Wrin T, Segal MR, Ramstead CA, Liegler TJ, Busch MP, Petropoulos CJ, Hellmann NS, Kahn JO, Grant RM

Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load.

Blood

Deeks SG, Kitchen CM, Liu L, Guo H, Gascon R, Narváez AB, Hunt P, Martin JN, Kahn JO, Levy J, McGrath MS, Hecht FM

Effect of IL-2 therapy on CD8+ cell noncytotoxic anti-HIV response during primary HIV-1 infection.

Journal of clinical immunology

Martinez-Mariño B, Ashlock BM, Shiboski S, Hecht FM, Levy JA

Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.

AIDS (London, England)

Altfeld M, Addo MM, Rosenberg ES, Hecht FM, Lee PK, Vogel M, Yu XG, Draenert R, Johnston MN, Strick D, Allen TM, Feeney ME, Kahn JO, Sekaly RP, Levy JA, Rockstroh JK, Goulder PJ, Walker BD

Development of a new less-sensitive enzyme immunoassay for detection of early HIV-1 infection.

Journal of acquired immune deficiency syndromes (1999)

Rawal BD, Degula A, Lebedeva L, Janssen RS, Hecht FM, Sheppard HW, Busch MP

Absolute or total lymphocyte count as a marker for the CD4 T lymphocyte criterion for initiating antiretroviral therapy.

AIDS (London, England)

Jacobson MA, Liu L, Khayam-Bashi H, Deeks SG, Hecht FM, Kahn J

Greater reversal of CD4+ cell abnormalities and viral load reduction after initiation of antiretroviral therapy with zidovudine, lamivudine, and nelfinavir before complete HIV type 1 seroconversion.

AIDS research and human retroviruses

Smith DE, Kaufmann GR, Kahn JO, Hecht FM, Grey PA, Zaunders JJ, Cunningham PH, Carr A, Duncombe C, Quan DC, Petersen A, Cooper DA

Changes in HIV testing after implementation of name-based HIV case surveillance in New Mexico.

American journal of public health

Lansky A, Lehman JS, Gatwood J, Hecht FM, Fleming PL

HIV testing within at-risk populations in the United States and the reasons for seeking or avoiding HIV testing.

Journal of acquired immune deficiency syndromes (1999)

Kellerman SE, Lehman JS, Lansky A, Stevens MR, Hecht FM, Bindman AB, Wortley PM

What happened to home HIV test collection kits? Intent to use kits, actual use, and barriers to use among persons at risk for HIV infection.

AIDS care

Colfax GN, Lehman JS, Bindman AB, Vittinghoff E, Vranizan K, Fleming PL, Chesney M, Osmond D, Hecht FM

Time trends in primary HIV-1 drug resistance among recently infected persons.

JAMA

Grant RM, Hecht FM, Warmerdam M, Liu L, Liegler T, Petropoulos CJ, Hellmann NS, Chesney M, Busch MP, Kahn JO

Increased HLA-DR expression on peripheral blood monocytes in subsets of subjects with primary HIV infection is associated with elevated CD4 T-cell apoptosis and CD4 T-cell depletion.

Journal of acquired immune deficiency syndromes (1999)

Gascon RL, Narváez AB, Zhang R, Kahn JO, Hecht FM, Herndier BG, McGrath MS

Use of laboratory tests and clinical symptoms for identification of primary HIV infection.

AIDS (London, England)

Hecht FM, Busch MP, Rawal B, Webb M, Rosenberg E, Swanson M, Chesney M, Anderson J, Levy J, Kahn JO

HIV expertise: a roundtable.

AIDS clinical care

Boswell SL, Hecht FM, Powderly WG, Soloway B, Volberding PA

Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.

Journal of virology

Day CL, Shea AK, Altfeld MA, Olson DP, Buchbinder SP, Hecht FM, Rosenberg ES, Walker BD, Kalams SA

Improving on a coin toss to predict patient adherence to medications.

Annals of internal medicine

Turner BJ, Hecht FM

Provider assessment of adherence to HIV antiretroviral therapy.

Journal of acquired immune deficiency syndromes (1999)

Bangsberg DR, Hecht FM, Clague H, Charlebois ED, Ciccarone D, Chesney M, Moss A

Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.

The Journal of experimental medicine

Altfeld M, Rosenberg ES, Shankarappa R, Mukherjee JS, Hecht FM, Eldridge RL, Addo MM, Poon SH, Phillips MN, Robbins GK, Sax PE, Boswell S, Kahn JO, Brander C, Goulder PJ, Levy JA, Mullins JI, Walker BD

Reduction in CD8+ cell noncytotoxic anti-HIV activity in individuals receiving highly active antiretroviral therapy during primary infection.

Proceedings of the National Academy of Sciences of the United States of America

Stranford SA, Ong JC, Martinez-Marino B, Busch M, Hecht FM, Kahn J, Levy JA

Why does Pneumocystis carinii pneumonia still occur?

AIDS (London, England)

Huang L, Hecht FM

Does HIV reporting by name deter testing? MESH Study Group.

AIDS (London, England)

Hecht FM, Chesney MA, Lehman JS, Osmond D, Vranizan K, Colman S, Keane D, Reingold A, Bindman AB

Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population.

AIDS (London, England)

Bangsberg DR, Hecht FM, Charlebois ED, Zolopa AR, Holodniy M, Sheiner L, Bamberger JD, Chesney MA, Moss A

Name-based surveillance and public health interventions for persons with HIV infection. Multistate Evaluation of Surveillance for HIV Study Group.

Annals of internal medicine

Osmond DH, Bindman AB, Vranizan K, Lehman JS, Hecht FM, Keane D, Reingold A

Optimizing care for persons with HIV infection. Society of General Internal Medicine AIDS Task Force.

Annals of internal medicine

Hecht FM, Wilson IB, Wu AW, Cook RL, Turner BJ

Antiretrovirals for HIV nephropathy?

AIDS clinical care

Saag M, Hecht F

HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: response to both initial and salvage therapy.

AIDS (London, England)

Deeks SG, Hecht FM, Swanson M, Elbeik T, Loftus R, Cohen PT, Grant RM

Adherence: a necessity for successful HIV combination therapy.

AIDS (London, England)

Chesney MA, Ickovics J, Hecht FM, Sikipa G, Rabkin J

Sexual transmission of an HIV-1 variant resistant to multiple reverse-transcriptase and protease inhibitors.

The New England journal of medicine

Hecht FM, Grant RM, Petropoulos CJ, Dillon B, Chesney MA, Tian H, Hellmann NS, Bandrapalli NI, Digilio L, Branson B, Kahn JO

New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes.

JAMA

Janssen RS, Satten GA, Stramer SL, Rawal BD, O'Brien TR, Weiblen BJ, Hecht FM, Jack N, Cleghorn FR, Kahn JO, Chesney MA, Busch MP

Itraconazole maintenance treatment for histoplasmosis in AIDS: a prospective, multicenter trial.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association

Hecht FM, Wheat J, Korzun AH, Hafner R, Skahan KJ, Larsen R, Limjoco MT, Simpson M, Schneider D, Keefer MC, Clark R, Lai KK, Jacobson JM, Squires K, Bartlett JA, Powderly W

Protease inhibitors in the homeless.

JAMA

Bangsberg D, Tulsky JP, Hecht FM, Moss AR

[Reevaluation of surgical treatment of cancers of the anus. Therapeutic proposals based on an experience with 33 patients].

Chirurgie; memoires de l'Academie de chirurgie

Benhamou G, Opsahl S, Vinardi O, Hecht F, Vilotte J

A new focus on primary HIV infection.

AIDS clinical care

Hecht F

Murder of son with a genital malformation.

American journal of medical genetics

Hecht BK, Hecht F

Suspected Pneumocystis carinii pneumonia with a negative induced sputum examination. Is early bronchoscopy useful?

American journal of respiratory and critical care medicine

Huang L, Hecht FM, Stansell JD, Montanti R, Hadley WK, Hopewell PC

H. influenzae vaccines in HIV.

The New England journal of medicine

Hecht FM

Clinical and biologic characterization of T-cell neoplasias with rearrangements of chromosome 7 band q34.

Blood

Smith SD, Morgan R, Gemmell R, Amylon MD, Link MP, Linker C, Hecht BK, Warnke R, Glader BE, Hecht F

Mutations of the Kirsten-ras proto-oncogene in human preleukaemia.

Nature

Liu E, Hjelle B, Morgan R, Hecht F, Bishop JM

Lymphocyte subpopulation profiles and mitogen kinetics in immunological deficiency testing.

Journal of clinical immunology

Radvany RM, Schubert MS, Kiamar M, Jarzabek V, Koehler-Carone K, Kuban D, Hecht F

Cytogenetic analyses in 89 patients with secondary hematologic disorders--results of a cooperative study.

Cancer genetics and cytogenetics

Zaccaria A, Alimena G, Baccarani M, Billström R, Carbonell F, Castoldi GL, Fuscaldo K, Hecht F, Hossfeld DK, Mitelman F

"I accuse" the Journal of unfair journalism.

The New England journal of medicine

Hecht F

Chromosome changes connect immunodeficiency and cancer in ataxia-telangiectasia.

The American journal of pediatric hematology/oncology

Hecht F, Hecht BK

Chromosome 9 abnormalities in childhood T-cell leukemia.

The New England journal of medicine

Smith SD, Link MP, Trela M, Amylon M, Sklar J, Morgan R, Hecht F

Chromosome 5q35 breakpoint in malignant histiocytosis.

The New England journal of medicine

Morgan R, Hecht BK, Sandberg AA, Hecht F, Smith SD

Translocations in T-cell leukemia in lymphoma.

The New England journal of medicine

Hecht F, Morgan R, Gemmill RM, Hecht BK

Caution about chorionic villi sampling in the first trimester.

The New England journal of medicine

Hecht F, Hecht BK, Bixenman HA

Antibiotics containing trimethoprim and the fragile X chromosome.

The New England journal of medicine

Hecht F, Glover TW

Immunoglobulin expression in Burkitt's lymphoma and leukemia.

The New England journal of medicine

Hecht F, Kaiser-McCaw B

The physician as a risk factor in midtrimester amniocentesis.

The New England journal of medicine

Hecht F

A surgical approach to the treatment of fetal hydrocephalus.

The New England journal of medicine

Clewell WH, Johnson ML, Meier PR, Newkirk JB, Zide SL, Hendee RW, Bowes WA, Hecht F, O'Keeffe D, Henry GP, Shikes RH

Placement of ventriculo-amniotic shunt for hydrocephalus in a fetus.

The New England journal of medicine

Clewell WH, Johnson ML, Meier PR, Newkirk JB, Hendee RW, Bowes WA, Zide SL, Hecht F, Henry G, O'Keeffe D

Chromosome translocations in cancer.

The New England journal of medicine

Hecht F, Kaiser-McCaw B, Sandberg AA

Position effect in 8;14 translocation in Burkitt's lymphoma.

The New England journal of medicine

Hecht F, Kaiser-McCaw B

The decline of NIH's peer-review system?

The New England journal of medicine

Hecht F

Linkage group I: multipoint mapping.

Birth defects original article series

Meyers DA, Conneally PM, Hecht F, Lovrien EW, Magenis E, Merritt AD, Palmer CG, Rivas ML, Wang L

Linkage group I: multipoint mapping.

Cytogenetics and cell genetics

Meyers DA, Conneally PM, Hecht F, Lovrien EW, Magenis E, Merritt AD, Palmer GC, Rivas ML, Wang L

Linkage relationships of 1qh to Amy, Fy, PGM1, and Rh.

Birth defects original article series

Rivas ML, Conneally PM, Hecht F, Lovrien EW, Magenis E, Merritt AD, Meyers DA, Palmer CG, Wang L

Linkage relationships of 1qh to Amy, Fy, PGM1, and Rh.

Cytogenetics and cell genetics

Rivas ML, Conneally PM, Hecht F, Lovrien EW, Magenis E, Merritt AD, Meyers DA, Palmer CG, Wang L