Synthia Mellon, PhD | Aging, Metabolism and Emotion Center

Cognitive function in physically healthy, unmedicated individuals with major depression: Relationship with depressive symptoms and antidepressant response.

Journal of affective disorders

Ou A, Wu GWY, Kassel MT, Mackin RS, Rampersaud R, Reus VI, Mellon SH, Wolkowitz OM

Kynurenine Metabolism is Associated with Antidepressant Response to Selective Serotonin Reuptake Inhibitors.

bioRxiv : the preprint server for biology

Rampersaud R, Suneson K, Wu GWY, Reus VI, Lindqvist D, Ho TC, Meyerhoff DJ, Irwin MR, Wolkowitz OM, Mellon SH, Brundin L

Serum brain-derived neurotrophic factor, Val66Met polymorphism and open-label SSRI treatment response in Major Depressive Disorder.

Psychoneuroendocrinology

Smit AJT, Wu GWY, Rampersaud R, Reus VI, Wolkowitz OM, Mellon SH

Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD.

Translational psychiatry

Blalock ZN, Wu GWY, Lindqvist D, Trumpff C, Flory JD, Lin J, Reus VI, Rampersaud R, Hammamieh R, Gautam A, SBPBC, Doyle FJ, Marmar CR, Jett M, Yehuda R, Wolkowitz OM, Mellon SH

Integrated analysis of proteomics, epigenomics and metabolomics data revealed divergent pathway activation patterns in the recent versus chronic post-traumatic stress disorder.

Brain, behavior, and immunity

Muhie S, Gautam A, Misganaw B, Yang R, Mellon SH, Hoke A, Flory J, Daigle B, Swift K, PTSD Systems Biology Consortium, Hood L, Doyle FJ, Wolkowitz OM, Marmar CR, Ressler K, Yehuda R, Hammamieh R, Jett M

Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression.

Scientific reports

Rampersaud R, Wu GWY, Reus VI, Lin J, Blackburn EH, Epel ES, Hough CM, Mellon SH, Wolkowitz OM

Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers.

Cell reports. Medicine

Muhie S, Gautam A, Yang R, Misganaw B, Daigle BJ, Mellon SH, Flory JD, Abu-Amara D, Lee I, Wang K, Rampersaud R, PTSD Systems Biology Consortium, Hood L, Yehuda R, Marmar CR, Wolkowitz OM, Ressler KJ, Doyle FJ, Hammamieh R, Jett M

The Genetic Basis for the Increased Prevalence of Metabolic Syndrome among Post-Traumatic Stress Disorder Patients.

International journal of molecular sciences

Misganaw B, Yang R, Gautam A, Muhie S, Mellon SH, Wolkowitz OM, Ressler KJ, Doyle FJ, Marmar CR, Jett M, Hammamieh R

Dimensions of childhood adversity differentially affect biological aging in major depression.

Translational psychiatry

Rampersaud R, Protsenko E, Yang R, Reus V, Hammamieh R, Wu GWY, Epel E, Jett M, Gautam A, Mellon SH, Wolkowitz OM

Blood-based mitochondrial respiratory chain function in major depression.

Translational psychiatry

Fernström J, Mellon SH, McGill MA, Picard M, Reus VI, Hough CM, Lin J, Epel ES, Wolkowitz OM, Lindqvist D

Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder.

Molecular psychiatry

Goetzl EJ, Wolkowitz OM, Srihari VH, Reus VI, Goetzl L, Kapogiannis D, Heninger GR, Mellon SH

Correction: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD.

Molecular psychiatry

Yang R, Wu GWY, Verhoeven JE, Gautam A, Reus VI, Kang JI, Flory JD, Abu-Amara D, Hood L, Doyle FJ, Yehuda R, Marmar CR, Jett M, Hammamieh R, Mellon SH, Wolkowitz OM

Serum brain-derived neurotrophic factor remains elevated after long term follow-up of combat veterans with chronic post-traumatic stress disorder.

Psychoneuroendocrinology

Wu GWY, Wolkowitz OM, Reus VI, Kang JI, Elnar M, Sarwal R, Flory JD, Abu-Amara D, Hammamieh R, Gautam A, Doyle FJ, Yehuda R, Marmar CR, Jett M, Mellon SH, SBPBC

Utilization of machine learning for identifying symptom severity military-related PTSD subtypes and their biological correlates.

Translational psychiatry

Siegel CE, Laska EM, Lin Z, Xu M, Abu-Amara D, Jeffers MK, Qian M, Milton N, Flory JD, Hammamieh R, Daigle BJ, Gautam A, Dean KR, Reus VI, Wolkowitz OM, Mellon SH, Ressler KJ, Yehuda R, Wang K, Hood L, Doyle FJ, Jett M, Marmar CR

"GrimAge," an epigenetic predictor of mortality, is accelerated in major depressive disorder.

Translational psychiatry

Protsenko E, Yang R, Nier B, Reus V, Hammamieh R, Rampersaud R, Wu GWY, Hough CM, Epel E, Prather AA, Jett M, Gautam A, Mellon SH, Wolkowitz OM

Epigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males.

Molecular psychiatry

Yang R, Gautam A, Getnet D, Daigle BJ, Miller S, Misganaw B, Dean KR, Kumar R, Muhie S, Wang K, Lee I, Abu-Amara D, Flory JD, Hood L, Wolkowitz OM, Mellon SH, Doyle FJ, Yehuda R, Marmar CR, Ressler KJ, Hammamieh R, Jett M

Pre-deployment risk factors for PTSD in active-duty personnel deployed to Afghanistan: a machine-learning approach for analyzing multivariate predictors.

Molecular psychiatry

Schultebraucks K, Qian M, Abu-Amara D, Dean K, Laska E, Siegel C, Gautam A, Guffanti G, Hammamieh R, Misganaw B, Mellon SH, Wolkowitz OM, Blessing EM, Etkin A, Ressler KJ, Doyle FJ, Jett M, Marmar CR

Pre-treatment allostatic load and metabolic dysregulation predict SSRI response in major depressive disorder: a preliminary report.

Psychological medicine

Hough CM, Bersani FS, Mellon SH, Morford AE, Lindqvist D, Reus VI, Epel ES, Wolkowitz OM

A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD.

Molecular psychiatry

Yang R, Wu GWY, Verhoeven JE, Gautam A, Reus VI, Kang JI, Flory JD, Abu-Amara D

Role of enhanced glucocorticoid receptor sensitivity in inflammation in PTSD: Insights from computational model for circadian-neuroendocrine-immune interactions.

American journal of physiology. Endocrinology and metabolism

Somvanshi PR, Mellon SH, Yehuda R, Flory JD, Bierer L, Makotkine I, Marmar C, Jett M, Doyle Iii FJ

Effect of Combat Exposure and Posttraumatic Stress Disorder on Telomere Length and Amygdala Volume.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Kang JI, Mueller SG, Wu GWY, Lin J, Ng P, Yehuda R, Flory JD, Abu-Amara D, Reus VI, Gautam A

Vitamin D and inflammation in major depressive disorder.

Journal of affective disorders

Grudet C, Wolkowitz OM, Mellon SH, Malm J, Reus VI, Brundin L, Nier BM, Dhabhar FS, Hough CM, Westrin Å, Lindqvist D

Novel Pharmacological Targets for Combat PTSD-Metabolism, Inflammation, The Gut Microbiome, and Mitochondrial Dysfunction.

Military medicine

Bersani FS, Mellon SH, Lindqvist D, Kang JI, Rampersaud R, Somvanshi PR, Doyle FJ, Hammamieh R, Jett M, Yehuda R, Marmar CR, Wolkowitz OM

Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder.

Molecular psychiatry

Dean KR, Hammamieh R, Mellon SH, Abu-Amara D, Flory JD, Guffanti G, Wang K, Daigle BJ, Gautam A, Lee I, Yang R, Almli LM, Bersani FS, Chakraborty N, Donohue D, Kerley K, Kim TK, Laska E, Young Lee M, Lindqvist D, Lori A, Lu L, Misganaw B, Muhie S, Newman J, Price ND, Qin S, Reus VI, Siegel C, Somvanshi PR, Thakur GS, Zhou Y

Accelerated aging in serious mental disorders.

Current opinion in psychiatry

Bersani FS, Mellon SH, Reus VI, Wolkowitz OM

Cortisol, moderated by age, is associated with antidepressant treatment outcome and memory improvement in Major Depressive Disorder: A retrospective analysis.

Psychoneuroendocrinology

Jain FA, Connolly CG, Reus VI, Meyerhoff DJ, Yang TT, Mellon SH, Mackin S, Hough CM, Morford A, Wolkowitz OM

Mechanistic inferences on metabolic dysfunction in PTSD from an integrated model and multi-omic analysis: Role of glucocorticoid receptor sensitivity.

American journal of physiology. Endocrinology and metabolism

Somvanshi PR, Mellon SH, Flory JD, Abu-Amara D, Consortium PSB, Wolkowitz OM, Yehuda R, Jett M, Hood L, Marmar C, Doyle FJ

Accelerating research on biological aging and mental health: Current challenges and future directions.

Psychoneuroendocrinology

Han LKM, Verhoeven JE, Tyrka AR, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Boks MP, Révész D, Mellon SH, Picard M

Metabolomic analysis of male combat veterans with post traumatic stress disorder.

PloS one

Mellon SH, Bersani FS, Lindqvist D, Hammamieh R, Donohue D, Dean K, Jett M, Yehuda R, Flory J, Reus VI, Bierer LM, Makotkine I, Abu Amara D, Henn Haase C, Coy M, Doyle FJ, Marmar C, Wolkowitz OM

Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder.

Psychiatry research

Khan MS, Wu GWY, Reus VI, Hough CM, Lindqvist D, Westrin Å, Nier BM, Wolkowitz OM, Mellon SH

Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status.

Molecular neuropsychiatry

Verhoeven JE, Yang R, Wolkowitz OM, Bersani FS, Lindqvist D, Mellon SH, Yehuda R, Flory JD, Lin J, Abu-Amara D, Makotkine I, Marmar C, Jett M, Hammamieh R

Posttraumatic stress disorder, symptoms, and white matter abnormalities among combat-exposed veterans.

Brain imaging and behavior

Aschbacher K, Mellon SH, Wolkowitz OM, Henn-Haase C, Yehuda R, Flory JD, Bierer LM, Abu-Amara D, Marmar CR, Mueller SG

Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder.

Biological psychiatry

Mellon SH, Gautam A, Hammamieh R, Jett M, Wolkowitz OM

Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Lindqvist D, Wolkowitz OM, Picard M, Ohlsson L, Bersani FS, Fernström J, Westrin Å, Hough CM, Lin J, Reus VI, Epel ES, Mellon SH

Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity.

Psychiatry research

Lindqvist D, Mellon SH, Dhabhar FS, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Aschbacher K, Bersani FS, Marmar CR, Wolkowitz OM

Whole-genome DNA methylation status associated with clinical PTSD measures of OIF/OEF veterans.

Translational psychiatry

Hammamieh R, Chakraborty N, Gautam A, Muhie S, Yang R, Donohue D, Kumar R, Daigle BJ, Zhang Y, Amara DA, Miller SA, Srinivasan S, Flory J, Yehuda R, Petzold L, Wolkowitz OM, Mellon SH, Hood L, Doyle FJ, Marmar C, Jett M

Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings.

Journal of psychosomatic research

Fair B, Mellon SH, Epel ES, Lin J, Révész D, Verhoeven JE, Penninx BW, Reus VI, Rosser R, Hough CM, Mahan L, Burke HM, Blackburn EH, Wolkowitz OM

Severity of anxiety- but not depression- is associated with oxidative stress in Major Depressive Disorder.

Journal of affective disorders

Steenkamp LR, Hough CM, Reus VI, Jain FA, Epel ES, James SJ, Morford AE, Mellon SH, Wolkowitz OM, Lindqvist D

Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans.

Psychoneuroendocrinology

Blessing EM, Reus V, Mellon SH, Wolkowitz OM, Flory JD, Bierer L, Lindqvist D, Dhabhar F, Li M, Qian M, Abu-Amara D, Galatzer-Levy I, Yehuda R, Marmar CR

Higher serum DHEA concentrations before and after SSRI treatment are associated with remission of major depression.

Psychoneuroendocrinology

Hough CM, Lindqvist D, Epel ES, Denis MS, Reus VI, Bersani FS, Rosser R, Mahan L, Burke HM, Wolkowitz OM, Mellon SH

Oxidative stress, inflammation and treatment response in major depression.

Psychoneuroendocrinology

Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH

The influence of cemented femoral stem choice on the incidence of revision for periprosthetic fracture after primary total hip arthroplasty: an analysis of national joint registry data.

The bone & joint journal

Palan J, Smith MC, Gregg P, Mellon S, Kulkarni A, Tucker K, Blom AW, Murray DW, Pandit H

Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study.

Brain, behavior, and immunity

Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Bersani FS, Marmar CR, Wolkowitz OM

Cortisol/DHEA ratio and hippocampal volume: A pilot study in major depression and healthy controls.

Psychoneuroendocrinology

Jin RO, Mason S, Mellon SH, Epel ES, Reus VI, Mahan L, Rosser RL, Hough CM, Burke HM, Mueller SG, Wolkowitz OM

Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report.

Molecular neuropsychiatry

Hough CM, Bersani FS, Mellon SH, Epel ES, Reus VI, Lindqvist D, Lin J, Mahan L, Rosser R, Burke H, Coetzee J, Nelson JC, Blackburn EH, Wolkowitz OM

Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment.

Translational psychiatry

Mellon SH, Wolkowitz OM, Schonemann MD, Epel ES, Rosser R, Burke HB, Mahan L, Reus VI, Stamatiou D, Liew CC, Cole SW

A population of atypical CD56(-)CD16(+) natural killer cells is expanded in PTSD and is associated with symptom severity.

Brain, behavior, and immunity

Bersani FS, Wolkowitz OM, Milush JM, Sinclair E, Eppling L, Aschbacher K, Lindqvist D, Yehuda R, Flory J, Bierer LM, Matokine I, Abu-Amara D, Reus VI, Coy M, Hough CM, Marmar CR, Mellon SH

Neuroscience-informed Auditory Training in Schizophrenia: A Final Report of the Effects on Cognition and Serum Brain-Derived Neurotrophic Factor.

Schizophrenia research. Cognition

Fisher M, Mellon SH, Wolkowitz O, Vinogradov S

Association of dimensional psychological health measures with telomere length in male war veterans.

Journal of affective disorders

Bersani FS, Lindqvist D, Mellon SH, Epel ES, Yehuda R, Flory J, Henn-Hasse C, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM

Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.

Brain, behavior, and immunity

Bersani FS, Wolkowitz OM, Lindqvist D, Yehuda R, Flory J, Bierer LM, Makotine I, Abu-Amara D, Coy M, Reus VI, Epel ES, Marmar C, Mellon SH

Evidence for disrupted gray matter structural connectivity in posttraumatic stress disorder.

Psychiatry research

Mueller SG, Ng P, Neylan T, Mackin S, Wolkowitz O, Mellon S, Yan X, Flory J, Yehuda R, Marmar CR, Weiner MW

Telomerase activation as a possible mechanism of action for psychopharmacological interventions.

Drug discovery today

Bersani FS, Lindqvist D, Mellon SH, Penninx BW, Verhoeven JE, Révész D, Reus VI, Wolkowitz OM

Mitochondrial DNA copy number is reduced in male combat veterans with PTSD.

Progress in neuro-psychopharmacology & biological psychiatry

Bersani FS, Morley C, Lindqvist D, Epel ES, Picard M, Yehuda R, Flory J, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM, Mellon SH

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.

Neuroscience and biobehavioral reviews

Lindqvist D, Epel ES, Mellon SH, Penninx BW, Révész D, Verhoeven JE, Reus VI, Lin J, Mahan L, Hough CM, Rosser R, Bersani FS, Blackburn EH, Wolkowitz OM

PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression.

Psychiatry research

Wolkowitz OM, Mellon SH, Lindqvist D, Epel ES, Blackburn EH, Lin J, Reus VI, Burke H, Rosser R, Mahan L, Mackin S, Yang T, Weiner M, Mueller S

Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings.

Psychiatry research

Lindqvist D, Mueller S, Mellon SH, Su Y, Epel ES, Reus VI, Rosser R, Mahan L, Mackin RS, Yang TT, Wolkowitz OM

Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults.

Journal of affective disorders

Chen SH, Epel ES, Mellon SH, Lin J, Reus VI, Rosser R, Kupferman E, Burke H, Mahan L, Blackburn EH, Wolkowitz OM

Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress.

Brain, behavior, and immunity

Lindqvist D, Wolkowitz OM, Mellon S, Yehuda R, Flory JD, Henn-Haase C, Bierer LM, Abu-Amara D, Coy M, Neylan TC, Makotkine I, Reus VI, Yan X, Taylor NM, Marmar CR, Dhabhar FS

Dysregulated relationship of inflammation and oxidative stress in major depression.

Brain, behavior, and immunity

Rawdin BJ, Mellon SH, Dhabhar FS, Epel ES, Puterman E, Su Y, Burke HM, Reus VI, Rosser R, Hamilton SP, Nelson JC, Wolkowitz OM

A culture system to study oligodendrocyte myelination processes using engineered nanofibers.

Nature methods

Lee S, Leach MK, Redmond SA, Chong SY, Mellon SH, Tuck SJ, Feng ZQ, Corey JM, Chan JR

Expression of P450c17 in the human fetal nervous system.

Endocrinology

Schonemann MD, Muench MO, Tee MK, Miller WL, Mellon SH

Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke.

Translational stroke research

Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon SH, Young WL, Su H

Serum BDNF levels before treatment predict SSRI response in depression.

Progress in neuro-psychopharmacology & biological psychiatry

Wolkowitz OM, Wolf J, Shelly W, Rosser R, Burke HM, Lerner GK, Reus VI, Nelson JC, Epel ES, Mellon SH

Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings.

PloS one

Wolkowitz OM, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y, Reus VI, Rosser R, Burke HM, Kupferman E, Compagnone M, Nelson JC, Blackburn EH

Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response.

Molecular psychiatry

Wolkowitz OM, Mellon SH, Epel ES, Lin J, Reus VI, Rosser R, Burke H, Compagnone M, Nelson JC, Dhabhar FS, Blackburn EH

Of sound mind and body: depression, disease, and accelerated aging.

Dialogues in clinical neuroscience

Wolkowitz OM, Reus VI, Mellon SH

Estrogen receptor beta-selective agonists stimulate calcium oscillations in human and mouse embryonic stem cell-derived neurons.

PloS one

Zhang L, Blackman BE, Schonemann MD, Zogovic-Kapsalis T, Pan X, Tagliaferri M, Harris HA, Cohen I, Pera RA, Mellon SH, Weiner RI, Leitman DC

Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder.

Progress in neuro-psychopharmacology & biological psychiatry

Berger W, Mehra A, Lenoci M, Metzler TJ, Otte C, Tarasovsky G, Mellon SH, Wolkowitz OM, Marmar CR, Neylan TC

Depression gets old fast: do stress and depression accelerate cell aging?

Depression and anxiety

Wolkowitz OM, Epel ES, Reus VI, Mellon SH

Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance.

Journal of immunological methods

Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S, Blackburn E

Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression.

Journal of psychiatric research

Dhabhar FS, Burke HM, Epel ES, Mellon SH, Rosser R, Reus VI, Wolkowitz OM

Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?

Biological psychiatry

Vinogradov S, Fisher M, Holland C, Shelly W, Wolkowitz O, Mellon SH

Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS).

Frontiers in neuroendocrinology

Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH

Regulation of P450c17 expression in the early embryo depends on GATA factors.

Endocrinology

Shi Y, Schonemann MD, Mellon SH

Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone.

Journal of cellular and molecular medicine

Zampieri S, Mellon SH, Butters TD, Nevyjel M, Covey DF, Bembi B, Dardis A

When blue turns to grey: do stress and depression accelerate cell aging?

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Wolkowitz OM, Epel ES, Mellon S

Neurosteroid regulation of central nervous system development.

Pharmacology & therapeutics

Mellon SH

Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease.

Brain research reviews

Mellon SH, Gong W, Schonemann MD

Translin coactivates steroidogenic factor-1-stimulated transcription.

Molecular endocrinology (Baltimore, Md.)

Mellon SH, Bair SR, Depoix C, Vigne JL, Hecht NB, Brake PB

Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.

Proceedings of the National Academy of Sciences of the United States of America

Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS

DNA sequence-dependent regulation of SF-1-mediated transcription.

DNA and cell biology

Brake PB, Bair SR, Mellon SH

Niemann pick type C disease as a model for defects in neurosteroidogenesis.

Endocrine research

Mellon S, Gong W, Griffin LD

Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone.

Nature medicine

Griffin LD, Gong W, Verot L, Mellon SH

Deletion of the mouse P450c17 gene causes early embryonic lethality.

Molecular and cellular biology

Bair SR, Mellon SH

The Endocrine Society Ethics Advisory Committee: ethical aspects of conflicts of interests, October 2003.

Endocrinology

Komesaroff PA, Bach MA, Danoff A, Grumbach MM, Kaplan S, Lakoski JM, Leitman D, Mellon S, Underwood LE, Leupen S

Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha.

Molecular and cellular biology

Hong CY, Park JH, Ahn RS, Im SY, Choi HS, Soh J, Mellon SH, Lee K

Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.

Endocrinology

Hammer F, Compagnone NA, Vigne JL, Bair SR, Mellon SH

Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17.

The Journal of biological chemistry

Pandey AV, Mellon SH, Miller WL

Synthesis, regulation, and function of neurosteroids.

Endocrine research

Mellon SH, Griffin LD

Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1alpha-hydroxylase gene expression in the proximal renal tubule.

Endocrinology

Zhang MY, Wang X, Wang JT, Compagnone NA, Mellon SH, Olson JL, Tenenhouse HS, Miller WL, Portale AA

Neurosteroids: biochemistry and clinical significance.

Trends in endocrinology and metabolism: TEM

Mellon SH, Griffin LD

Biosynthesis and action of neurosteroids.

Brain research. Brain research reviews

Mellon SH, Griffin LD, Compagnone NA

Biosynthesis of the neurosteroid 3 alpha-hydroxy-4-pregnen-20-one (3 alpha hp), a specific inhibitor of FSH release.

Endocrinology

Griffin LD, Mellon SH

Developmental gonadal expression of the transcription factor SET and its target gene, P450c17 (17alpha-hydroxylase/c17,20 lyase).

DNA and cell biology

Zhang P, Compagnone NA, Fiore C, Vigne JL, Culp P, Musci TJ, Mellon SH

Regulation of uterine gamma-aminobutyric acid(A) receptor subunit expression throughout pregnancy.

Endocrinology

Fujii E, Mellon SH

Biosynthesis of neurosteroids and regulation of their synthesis.

International review of neurobiology

Mellon SH, Vaudry H

Current perspectives on the role of neurosteroids in PMS and depression.

International review of neurobiology

Griffin LD, Conrad SC, Mellon SH

Modulation of steroidogenesis by selenium in a novel adrenal cell line developed using targeted tumorigenesis.

BioFactors (Oxford, England)

Chanoine JP, Compagnone NA, Wong AC, Mellon SH

Opposing early inhibitory and late stimulatory effects of insulin-like growth factor-I on myogenin gene transcription.

Journal of cellular biochemistry

Adi S, Cheng ZQ, Zhang PL, Wu NY, Mellon SH, Rosenthal SM

Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis.

Molecular endocrinology (Baltimore, Md.)

Compagnone NA, Zhang P, Vigne JL, Mellon SH

Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction.

Recent progress in hormone research

Ingraham HA, Hirokawa Y, Roberts LM, Mellon SH, McGee E, Nachtigal MW, Visser JA

Neurosteroids: biosynthesis and function of these novel neuromodulators.

Frontiers in neuroendocrinology

Compagnone NA, Mellon SH

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.

Proceedings of the National Academy of Sciences of the United States of America

Griffin LD, Mellon SH

Ku autoimmune antigen is involved in placental regulation of rat P450c17 gene transcription.

DNA and cell biology

Zhang P, Hammer F, Bair S, Wang J, Reeves WH, Mellon SH

Orphan receptors, proto-oncogenes and other nuclear factors regulate P450C17 gene transcription.

Endocrine research

Mellon SH, Compagnone NA, Zhang P

25-Hydroxycholesterol is not a ligand for the orphan nuclear receptor steroidogenic factor-1 (SF-1).

Endocrinology

Mellon SH, Bair SR

Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development.

Proceedings of the National Academy of Sciences of the United States of America

Compagnone NA, Mellon SH

Polyribonucleotide phosphorylase is a double-stranded DNA-binding protein.

DNA and cell biology

Zhang P, Vigne JL, Mellon SH

Expression of steroid sulfatase during embryogenesis.

Endocrinology

Compagnone NA, Salido E, Shapiro LJ, Mellon SH

Multiple orphan nuclear receptors converge to regulate rat P450c17 gene transcription: novel mechanisms for orphan nuclear receptor action.

Molecular endocrinology (Baltimore, Md.)

Zhang P, Mellon SH

Characterization of adrenocortical cell lines produced by genetically targeted tumorigenesis in transgenic mice.

Steroids

Compagnone NA, Bair SR, Mellon SH

The testis and the adrenal are (transcriptionally) the same.

Steroids

Mellon SH, Zhang P

Enzymatic properties of transplanted glomerulosa cells.

World journal of surgery

Scheumann GF, Heitmann P, Teebken OE, Mössinger E, Mellon SH, Pichlmayr R

Cytochrome P450 17 alpha-hydroxylase gene expression in differentiating rat trophoblast cells.

The Journal of endocrinology

Yamamoto T, Chapman BM, Johnson DC, Givens CR, Mellon SH, Soares MJ

Expression of the gene for cytochrome P-450 17 alpha-hydroxylase/C17-20 lyase (CYP17) in porcine Leydig cells: identification of a DNA sequence that mediates cAMP response.

Biochimica et biophysica acta

Zhang P, Han XG, Mellon SH, Hall PF

The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3',5'-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17 alpha-hydroxylase/c17-20 lyase).

Molecular endocrinology (Baltimore, Md.)

Zhang P, Mellon SH

Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system.

Endocrinology

Compagnone NA, Bulfone A, Rubenstein JL, Mellon SH

Transcriptional regulation of P450scc gene expression in neural and steroidogenic cells: implications for regulation of neurosteroidogenesis.

Molecular endocrinology (Baltimore, Md.)

Zhang P, Rodriguez H, Mellon SH

Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland.

Molecular endocrinology (Baltimore, Md.)

Allen RG, Carey C, Parker JD, Mortrud MT, Mellon SH, Low MJ

Molecular variants in the P450c11AS gene as determinants of aldosterone synthase activity in the Dahl rat model of hypertension.

The Journal of biological chemistry

Cover CM, Wang JM, St Lezin E, Kurtz TW, Mellon SH

Chronic dexamethasone treatment suppresses hypertension development in the transgenic rat TGR(mREN2)27.

Journal of hypertension

Djavidani B, Sander M, Kreutz R, Zeh K, Bader M, Mellon SH, Vecsei P, Peters J, Ganten D

Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.

Endocrinology

Compagnone NA, Bulfone A, Rubenstein JL, Mellon SH

Artificial mutations in P450c11AS (aldosterone synthase) can increase enzymatic activity: a model for low-renin hypertension?

The Journal of clinical endocrinology and metabolism

Fardella CE, Rodriguez H, Hum DW, Mellon SH, Miller WL

P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally, and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities.

The Journal of biological chemistry

Mellon SH, Bair SR, Monis H

Prenatal diagnosis of congenital lipoid adrenal hyperplasia.

The Journal of clinical endocrinology and metabolism

Saenger P, Klonari Z, Black SM, Compagnone N, Mellon SH, Fleischer A, Abrams CA, Shackelton CH, Miller WL

Rodent models for studying steroids and hypertension: from fetal development to cells in culture.

Steroids

Mellon SH, Compagnone N, Sander M, Cover C, Ganten D, Djavidani B

Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities.

DNA and cell biology

Givens CR, Zhang P, Bair SR, Mellon SH

Neurosteroids: biochemistry, modes of action, and clinical relevance.

The Journal of clinical endocrinology and metabolism

Mellon SH

Role of adrenal renin in the regulation of adrenal steroidogenesis by corticotropin.

Proceedings of the National Academy of Sciences of the United States of America

Sander M, Ganten D, Mellon SH

Steroidogenic adrenocortical cell lines produced by genetically targeted tumorigenesis in transgenic mice.

Molecular endocrinology (Baltimore, Md.)

Mellon SH, Miller WL, Bair SR, Moore CC, Vigne JL, Weiner RI

Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.

Brain research

Mellon SH, Deschepper CF

Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance.

Endocrinology

Moore CC, Mellon SH, Murai J, Siiteri PK, Miller WL

Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B.

The Journal of cell biology

Bristow J, Tee MK, Gitelman SE, Mellon SH, Miller WL

Mitogenic action, regulation, and localization of insulin-like growth factors in the human fetal adrenal gland.

The Journal of clinical endocrinology and metabolism

Mesiano S, Mellon SH, Jaffe RB

Basic fibroblast growth factor expression is regulated by corticotropin in the human fetal adrenal: a model for adrenal growth regulation.

Proceedings of the National Academy of Sciences of the United States of America

Mesiano S, Mellon SH, Gospodarowicz D, Di Blasio AM, Jaffe RB

Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues.

DNA and cell biology

Mellon SH, Kushner JA, Vaisse C

Zone-specific regulation of two messenger RNAs for P450c11 in the adrenals of pregnant and nonpregnant rats.

Proceedings of the National Academy of Sciences of the United States of America

Malee MP, Mellon SH

Human proopiomelanocortin-(79-96), a proposed androgen stimulatory hormone, does not affect steroidogenesis in cultured human fetal adrenal cells.

The Journal of clinical endocrinology and metabolism

Mellon SH, Shively JE, Miller WL

Tissue-specific, cyclic adenosine 3',5'-monophosphate-induced, and phorbol ester-repressed transcription from the human P450c17 promoter in mouse cells.

Molecular endocrinology (Baltimore, Md.)

Brentano ST, Picado-Leonard J, Mellon SH, Moore CC, Miller WL

Analysis by immunocytochemistry and in situ hybridization of renin and its mRNA in kidney, testis, adrenal, and pituitary of the rat.

Proceedings of the National Academy of Sciences of the United States of America

Deschepper CF, Mellon SH, Cumin F, Baxter JD, Ganong WF

An approach to the molecular biology of congenital adrenal hyperplasia.

Annals of the New York Academy of Sciences

Chung BC, Matteson KJ, Morin JE, Mellon SH, Miller WL

Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells.

DNA (Mary Ann Liebert, Inc.)

Karin M, Eberhardt NL, Mellon SH, Malich N, Richards RI, Slater EP, Barta A, Martial JA, Baxter JD, Cathala G

Growth hormone gene transcription is regulated by thyroid and glucocorticoid hormones in cultured rat pituitary tumor cells.

The Journal of biological chemistry

Spindler SR, Mellon SH, Baxter JD

Publications