Carl Grunfeld, MD

Prof in Rsd & Div Chief
Medicine
+1 415 750-2005

Dr. Grunfeld’s research involves two major areas. He studies how infection and inflammation affect metabolism and body composition, with a focus on ways those changes promote atherosclerosis. He also studies how disease and therapy affect kidney function with laboratory studies looking at novel markers in urine and blood.

Publications: 

Bone marrow adipose tissue composition and glycemic improvements after gastric bypass surgery.

Bone reports

Kim TY, Schwartz AV, Li X, Xu K, Kazakia GJ, Grunfeld C, Nissenson RA, Shoback DM, Schafer AL

The Heart and Cannabis (THC) Cohort: Differences in Baseline Health and Behaviors by Cannabis Use.

Journal of general internal medicine

Keyhani S, Cohen BE, Vali M, Hoggatt KJ, Bravata DM, Austin PC, Lum E, Hasin DS, Grunfeld C, Shlipak MG

Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality.

Journal of general internal medicine

Seal KH, Bertenthal D, Carey E, Grunfeld C, Bikle DD, Lu CM

Associations of CKD risk factors and longitudinal changes in urine biomarkers of kidney tubules among women living with HIV.

BMC nephrology

Muiru AN, Scherzer R, Ascher SB, Jotwani V, Grunfeld C, Shigenaga J, Spaulding KA, Ng DK, Gustafson D, Spence AB, Sharma A, Cohen MH, Parikh CR, Ix JH, Estrella MM, Shlipak MG

Kidney tubule health scores and their associations with incident CKD in women living with HIV.

HIV medicine

Ascher SB, Scherzer R, Estrella MM, Muiru AN, Jotwani VK, Grunfeld C, Shigenaga J, Spaulding KA, Ng DK, Gustafson D, Spence AB, Sharma A, Cohen MH, Parikh CR, Ix JH, Shlipak MG

Contributions of HIV, HCV, and traditional vascular risk factors to peripheral artery disease in women.

AIDS (London, England)

Cedarbaum E, Ma Y, Scherzer R, Price JC, Adimora AA, Bamman M, Cohen M, Fischl MA, Matsushita K, Ofotokun I, Plankey M, Seaberg EC, Yin MT, Grunfeld C, Vartanian S, Sharma A, Tien PC

Association of Statin Use with Kidney Damage and Function Among HIV-infected Men.

Journal of acquired immune deficiency syndromes (1999)

Ascher SB, Scherzer R, Nishtala A, Jotwani V, Grunfeld C, Parikh CR, Ng D, Wang R, Palella FJ, Shlipak MG, Estrella MM

Mortality following myocardial infarction among HIV-infected persons: the Center for AIDS Research Network Of Integrated Clinical Systems (CNICS).

BMC medicine

Feinstein MJ, Nance RM, Delaney JAC, Heckbert SR, Budoff MJ, Drozd DR, Burkholder GA, Willig JH, Mugavero MJ, Mathews WC, Moore RD, Eron JJ, Napravnik S, Hunt PW, Geng E, Hsue P, Peter I, Lober WB, Crothers K, Grunfeld C, Saag MS, Kitahata MM, Lloyd-Jones DM, Crane HM

Tenofovir disoproxil fumarate initiation and changes in urinary biomarker concentrations among HIV-infected men and women.

AIDS (London, England)

Zhang WR, Scherzer R, Estrella MM, Ascher SB, Muiru A, Jotwani V, Grunfeld C, Parikh CR, Gustafson D, Kassaye S, Sharma A, Cohen M, Tien PC, Ng DK, Palella FJ, Witt MD, Ho K, Shlipak MG

Leptinemia is Associated With Peripheral Artery Disease.

The Journal of surgical research

Zahner GJ, Ramirez JL, Spaulding KA, Khetani SA, Gasper WJ, Grunfeld C, Hills NK, Schafer AL, Grenon SM

Kidney disease risk factors associate with urine biomarkers concentrations in HIV-positive persons; a cross-sectional study.

BMC nephrology

Muiru AN, Shlipak MG, Scherzer R, Zhang WR, Ascher SB, Jotwani V, Grunfeld C, Parikh CR, Ng D, Palella FJ, Ho K, Kassaye S, Sharma A, Cohen M, Wang R, Qi Q, Estrella MM

Association of Urinary Biomarkers of Kidney Injury with Estimated GFR Decline in HIV-Infected Individuals following Tenofovir Disoproxil Fumarate Initiation.

Clinical journal of the American Society of Nephrology : CJASN

Ascher SB, Scherzer R, Estrella MM, Zhang WR, Muiru AN, Jotwani V, Grunfeld C, Parikh CR, Gustafson D, Young M, Sharma A, Cohen MH, Ng DK, Palella FJ, Witt MD, Ho K, Shlipak MG

Association of Biomarker Clusters With Cardiac Phenotypes and Mortality in Patients With HIV Infection.

Circulation. Heart failure

Scherzer R, Shah SJ, Secemsky E, Butler J, Grunfeld C, Shlipak MG, Hsue PY

Contribution of Liver Fibrosis and Microbial Translocation to Immune Activation in Persons Infected With HIV and/or Hepatitis C Virus.

The Journal of infectious diseases

Reid M, Ma Y, Scherzer R, Price JC, French AL, Huhn GD, Plankey MW, Peters M, Grunfeld C, Tien PC

CHA2DS2-VASc Score, Warfarin Use, and Risk for Thromboembolic Events Among HIV-Infected Persons With Atrial Fibrillation.

Journal of acquired immune deficiency syndromes (1999)

Chau KH, Scherzer R, Grunfeld C, Hsue PY, Shlipak MG

Association of Tenofovir Use With Risk of Incident Heart Failure in HIV-Infected Patients.

Journal of the American Heart Association

Chen R, Scherzer R, Hsue PY, Jotwani V, Estrella MM, Horberg MA, Grunfeld C, Shlipak MG

Types of Myocardial Infarction Among Human Immunodeficiency Virus-Infected Individuals in the United States.

JAMA cardiology

Crane HM, Paramsothy P, Drozd DR, Nance RM, Delaney JA, Heckbert SR, Budoff MJ, Burkholder GA, Willig JH, Mugavero MJ, Mathews WC, Crane PK, Moore RD, Eron JJ, Napravnik S, Hunt PW, Geng E, Hsue P, Rodriguez C, Peter I, Barnes GS, McReynolds J, Lober WB, Crothers K, Feinstein MJ, Grunfeld C, Saag MS, Kitahata MM

Associations Between At-Risk Alcohol Use, Substance Use, and Smoking with Lipohypertrophy and Lipoatrophy Among Patients Living with HIV.

AIDS research and human retroviruses

Noorhasan M, Drozd DR, Grunfeld C, Merrill JO, Burkholder GA, Mugavero MJ, Willig JH, Willig AL, Cropsey KL, Mayer KH, Blashill A, Mimiaga M, McCaul ME, Hutton H, Chander G, Mathews WC, Napravnik S, Eron JJ, Christopoulos K, Fredericksen RJ, Nance RM, Delaney JC, Crane PK, Saag MS, Kitahata MM, Crane HM

Higher CD163 levels are associated with insulin resistance in hepatitis C virus-infected and HIV-infected adults.

AIDS (London, England)

Reid M, Ma Y, Scherzer R, Price JC, French AL, Plankey MW, Grunfeld C, Tien PC

Association of serum albumin and aspartate transaminase with 5-year all-cause mortality in HIV/hepatitis C virus coinfection and HIV monoinfection.

AIDS (London, England)

Scherzer R, Heymsfield SB, Rimland D, Powderly WG, Tien PC, Bacchetti P, Shlipak MG, Grunfeld C

Association of Kidney Function and Early Kidney Injury With Incident Hypertension in HIV-Infected Women.

Hypertension (Dallas, Tex. : 1979)

Ascher SB, Scherzer R, Peralta CA, Tien PC, Grunfeld C, Estrella MM, Abraham A, Gustafson DR, Nowicki M, Sharma A, Cohen MH, Butch AW, Young MA, Bennett MR, Shlipak MG

Effect of inflammation on HDL structure and function.

Current opinion in lipidology

Feingold KR, Grunfeld C

Diabetes in HIV-infected persons in Cameroon?

Diabetes/metabolism research and reviews

Grunfeld C, Dankner R

HIV and Hepatitis C-Coinfected Patients Have Lower Low-Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent "PCSK9-Lipid Paradox".

Journal of the American Heart Association

Kohli P, Ganz P, Ma Y, Scherzer R, Hur S, Weigel B, Grunfeld C, Deeks S, Wasserman S, Scott R, Hsue PY

Effects of a mindfulness-based weight loss intervention in adults with obesity: A randomized clinical trial.

Obesity (Silver Spring, Md.)

Daubenmier J, Moran PJ, Kristeller J, Acree M, Bacchetti P, Kemeny ME, Dallman M, Lustig RH, Grunfeld C, Nixon DF, Milush JM, Goldman V, Laraia B, Laugero KD, Woodhouse L, Epel ES, Hecht FM

Use of cystatin C to inform metformin eligibility among adult veterans with diabetes.

Journal of clinical & translational endocrinology

Tuot DS, Scherzer R, Leong H, Hung AM, Grunfeld C, Shlipak MG

Association of HIV, Hepatitis C Virus, and Liver Fibrosis Severity With the Enhanced Liver Fibrosis Score.

The Journal of infectious diseases

Swanson S, Ma Y, Scherzer R, Huhn G, French AL, Plankey MW, Grunfeld C, Rosenberg WM, Peters MG, Tien PC

Association of HIV, hepatitis C virus and liver fibrosis severity with interleukin-6 and C-reactive protein levels.

AIDS (London, England)

Shah S, Ma Y, Scherzer R, Huhn G, French AL, Plankey M, Peters MG, Grunfeld C, Tien PC

Subchronic sleep restriction causes tissue-specific insulin resistance.

The Journal of clinical endocrinology and metabolism

Rao MN, Neylan TC, Grunfeld C, Mulligan K, Schambelan M, Schwarz JM

Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study.

Bone

Schafer AL, Li X, Schwartz AV, Tufts LS, Wheeler AL, Grunfeld C, Stewart L, Rogers SJ, Carter JT, Posselt AM, Black DM, Shoback DM

Teriparatide treatment of osteoporosis in an HIV-infected man: a case report and literature review.

AIDS (London, England)

Wheeler AL, Tien PC, Grunfeld C, Schafer AL

Deep sequencing of RYR3 gene identifies rare and common variants associated with increased carotid intima-media thickness (cIMT) in HIV-infected individuals.

Journal of human genetics

Zhi D, Shendre A, Scherzer R, Irvin MR, Perry RT, Levy S, Arnett DK, Grunfeld C, Shrestha S

Altered inflammatory activity associated with reduced hippocampal volume and more severe posttraumatic stress symptoms in Gulf War veterans.

Psychoneuroendocrinology

O'Donovan A, Chao LL, Paulson J, Samuelson KW, Shigenaga JK, Grunfeld C, Weiner MW, Neylan TC

Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis.

Journal of the American Heart Association

Hsue PY, Scherzer R, Grunfeld C, Imboden J, Wu Y, Del Puerto G, Nitta E, Shigenaga J, Schnell Heringer A, Ganz P, Graf J

Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages.

Journal of lipid research

Feingold KR, Moser A, Shigenaga JK, Grunfeld C

Hyperinsulinemic response to oral glucose challenge in individuals with posttraumatic stress disorder.

Psychoneuroendocrinology

Rao MN, Chau A, Madden E, Inslicht S, Talbot L, Richards A, O'Donovan A, Ruoff L, Grunfeld C, Neylan TC

Serum albumin and kidney function decline in HIV-infected women.

American journal of kidney diseases : the official journal of the National Kidney Foundation

Lang J, Scherzer R, Tien PC, Parikh CR, Anastos K, Estrella MM, Abraham AG, Sharma A, Cohen MH, Butch AW, Nowicki M, Grunfeld C, Shlipak MG

A chronic kidney disease risk score to determine tenofovir safety in a prospective cohort of HIV-positive male veterans.

AIDS (London, England)

Scherzer R, Gandhi M, Estrella MM, Tien PC, Deeks SG, Grunfeld C, Peralta CA, Shlipak MG

Monocyte activation from interferon-a in HIV infection increases acetylated LDL uptake and ROS production.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Pulliam L, Calosing C, Sun B, Grunfeld C, Rempel H

Association of glucocorticoid receptor haplotypes with body composition and metabolic parameters in HIV-infected patients from the FRAM study.

Pharmacogenetics and genomics

Manenschijn L, Scherzer R, Koper JW, Danoff A, van Rossum EF, Grunfeld C

HIV/hepatitis C virus coinfection ameliorates the atherogenic lipoprotein abnormalities of HIV infection.

AIDS (London, England)

Wheeler AL, Scherzer R, Lee D, Delaney JA, Bacchetti P, Shlipak MG, Sidney S, Grunfeld C, Tien PC

Urinary biomarkers of kidney injury are associated with all-cause mortality in the Women's Interagency HIV Study (WIHS).

HIV medicine

Peralta C, Scherzer R, Grunfeld C, Abraham A, Tien P, Devarajan P, Bennett M, Butch A, Anastos K, Cohen M, Nowicki M, Sharma A, Young M, Sarnak M, Parikh C, Shlipak M

HIV, inflammation, and calcium in atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology

Shrestha S, Irvin MR, Grunfeld C, Arnett DK

Does HIV infection promote early kidney injury in women?

Antiviral therapy

Jotwani V, Scherzer R, Abraham A, Estrella MM, Bennett M, Devarajan P, Anastos K, Cohen MH, Nowicki M, Sharma A, Young M, Tien PC, Grunfeld C, Parikh CR, Shlipak MG

The relationship between body mass index and mental health among Iraq and Afghanistan veterans.

Journal of general internal medicine

Maguen S, Madden E, Cohen B, Bertenthal D, Neylan T, Talbot L, Grunfeld C, Seal K

Serum albumin and short-term risk for mortality and cardiovascular disease among HIV-infected veterans.

AIDS (London, England)

Lang J, Scherzer R, Weekley CC, Tien PC, Grunfeld C, Shlipak MG

Elevated levels of asymmetric dimethylarginine are associated with lower CD4+ count and higher viral load in HIV-infected individuals.

Atherosclerosis

Parikh RV, Scherzer R, Grunfeld C, Nitta EM, Leone A, Martin JN, Deeks SG, Ganz P, Hsue PY

Atrial fibrillation and atrial flutter in human immunodeficiency virus-infected persons: incidence, risk factors, and association with markers of HIV disease severity.

Journal of the American College of Cardiology

Hsu JC, Li Y, Marcus GM, Hsue PY, Scherzer R, Grunfeld C, Shlipak MG

Ceramides stimulate caspase-14 expression in human keratinocytes.

Experimental dermatology

Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR

Urinary markers of kidney injury and kidney function decline in HIV-infected women.

Journal of acquired immune deficiency syndromes (1999)

Shlipak MG, Scherzer R, Abraham A, Tien PC, Grunfeld C, Peralta CA, Devarajan P, Bennett M, Butch AW, Anastos K, Cohen MH, Nowicki M, Sharma A, Young MA, Sarnak MJ, Parikh CR

Lipids: a key player in the battle between the host and microorganisms.

Journal of lipid research

Feingold KR, Grunfeld C

Mechanisms of triglyceride accumulation in activated macrophages.

Journal of leukocyte biology

Feingold KR, Shigenaga JK, Kazemi MR, McDonald CM, Patzek SM, Cross AS, Moser A, Grunfeld C

Psoriasis: it's more than just the skin.

Journal of lipid research

Feingold KR, Grunfeld C

Association of tenofovir exposure with kidney disease risk in HIV infection.

AIDS (London, England)

Scherzer R, Estrella M, Li Y, Choi AI, Deeks SG, Grunfeld C, Shlipak MG

Angiopoietin like protein 4 expression is decreased in activated macrophages.

Biochemical and biophysical research communications

Feingold KR, Shigenaga JK, Cross AS, Moser A, Grunfeld C

FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis.

Endocrinology

Feingold KR, Grunfeld C, Heuer JG, Gupta A, Cramer M, Zhang T, Shigenaga JK, Patzek SM, Chan ZW, Moser A, Bina H, Kharitonenkov A

HIV infection is associated with decreased thrombin generation.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Hsue PY, Scherzer R, Grunfeld C, Nordstrom SM, Schnell A, Kohl LP, Nitta E, Martin JN, Deeks SG, Weiss EJ

Incidence and risk factors for acute kidney injury in HIV Infection.

American journal of nephrology

Li Y, Shlipak MG, Grunfeld C, Choi AI

Relationship between MRI-measured bone marrow adipose tissue and hip and spine bone mineral density in African-American and Caucasian participants: the CARDIA study.

The Journal of clinical endocrinology and metabolism

Shen W, Scherzer R, Gantz M, Chen J, Punyanitya M, Lewis CE, Grunfeld C

Risk factors for ESRD in HIV-infected individuals: traditional and HIV-related factors.

American journal of kidney diseases : the official journal of the National Kidney Foundation

Jotwani V, Li Y, Grunfeld C, Choi AI, Shlipak MG

Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.

Pharmacogenetics and genomics

Irvin MR, Shrestha S, Chen YD, Wiener HW, Haritunians T, Vaughan LK, Tiwari HK, Taylor KD, Scherzer R, Saag MS, Grunfeld C, Rotter JI, Arnett DK

Association of low level viremia with inflammation and mortality in HIV-infected adults.

PloS one

Eastburn A, Scherzer R, Zolopa AR, Benson C, Tracy R, Do T, Bacchetti P, Shlipak M, Grunfeld C, Tien PC

Association of increased upper trunk and decreased leg fat with 2-h glucose in control and HIV-infected persons.

Diabetes care

Kosmiski LA, Scherzer R, Heymsfield SB, Rimland D, Simberkoff MS, Sidney S, Shlipak MG, Bacchetti P, Biggs ML, Grunfeld C

Decreased limb muscle and increased central adiposity are associated with 5-year all-cause mortality in HIV infection.

AIDS (London, England)

Scherzer R, Heymsfield SB, Lee D, Powderly WG, Tien PC, Bacchetti P, Shlipak MG, Grunfeld C

Inflammation inhibits GPR81 expression in adipose tissue.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Feingold KR, Moser A, Shigenaga JK, Grunfeld C

Regional fat deposition and cardiovascular risk in HIV infection: the FRAM study.

AIDS care

Lake JE, Wohl D, Scherzer R, Grunfeld C, Tien PC, Sidney S, Currier JS

Reduced kidney function and preclinical atherosclerosis in HIV-infected individuals: the study of fat redistribution and metabolic change in HIV infection (FRAM).

American journal of nephrology

Jotwani V, Scherzer R, Choi A, Szczech L, Polak JF, Kronmal RA, Grunfeld C, Shlipak M

Levels of plasma fibrinogen are elevated in well-controlled rheumatoid arthritis.

Rheumatology (Oxford, England)

Rooney T, Scherzer R, Shigenaga JK, Graf J, Imboden JB, Grunfeld C

Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals.

The journals of gerontology. Series A, Biological sciences and medical sciences

Yarasheski KE, Scherzer R, Kotler DP, Dobs AS, Tien PC, Lewis CE, Kronmal RA, Heymsfield SB, Bacchetti P, Grunfeld C

Impact of NRTIs on lipid levels among a large HIV-infected cohort initiating antiretroviral therapy in clinical care.

AIDS (London, England)

Crane HM, Grunfeld C, Willig JH, Mugavero MJ, Van Rompaey S, Moore R, Rodriguez B, Feldman BJ, Lederman MM, Saag MS, Kitahata MM

Uromodulin concentrations are not associated with incident CKD among persons with coronary artery disease.

BMC nephrology

Shlipak MG, Li Y, Fox C, Coresh J, Grunfeld C, Whooley M

Boosting dose ritonavir does not alter peripheral insulin sensitivity in healthy HIV-seronegative volunteers.

Journal of acquired immune deficiency syndromes (1999)

Taylor SA, Lee GA, Pao VY, Anthonypillai J, Aweeka FT, Schwarz JM, Mulligan K, Schambelan M, Grunfeld C

Inflammation and mortality in HIV-infected adults: analysis of the FRAM study cohort.

Journal of acquired immune deficiency syndromes (1999)

Tien PC, Choi AI, Zolopa AR, Benson C, Tracy R, Scherzer R, Bacchetti P, Shlipak M, Grunfeld C

The role of HDL in innate immunity.

Journal of lipid research

Feingold KR, Grunfeld C

Associations of antiretroviral drug use and HIV-specific risk factors with carotid intima-media thickness.

AIDS (London, England)

Delaney JA, Scherzer R, Biggs ML, Shliplak MG, Polak JF, Currier JS, Kronmal RA, Wanke C, Bacchetti P, O'leary D, Tien PC, Grunfeld C

Expression and regulation of GPAT isoforms in cultured human keratinocytes and rodent epidermis.

Journal of lipid research

Lu B, Jiang YJ, Kim P, Moser A, Elias PM, Grunfeld C, Feingold KR

Cystatin C, albuminuria, and 5-year all-cause mortality in HIV-infected persons.

American journal of kidney diseases : the official journal of the National Kidney Foundation

Choi A, Scherzer R, Bacchetti P, Tien PC, Saag MS, Gibert CL, Szczech LA, Grunfeld C, Shlipak MG

Dyslipidemia and its Treatment in HIV Infection.

Topics in HIV medicine : a publication of the International AIDS Society, USA

Grunfeld C

Regional adipose tissue measured by MRI over 5 years in HIV-infected and control participants indicates persistence of HIV-associated lipoatrophy.

AIDS (London, England)

Grunfeld C, Saag M, Cofrancesco J, Lewis CE, Kronmal R, Heymsfield S, Tien PC, Bacchetti P, Shlipak M, Scherzer R

Effects of insulin-like growth factor (IGF)-I/IGF-binding protein-3 treatment on glucose metabolism and fat distribution in human immunodeficiency virus-infected patients with abdominal obesity and insulin resistance.

The Journal of clinical endocrinology and metabolism

Rao MN, Mulligan K, Tai V, Wen MJ, Dyachenko A, Weinberg M, Li X, Lang T, Grunfeld C, Schwarz JM, Schambelan M

Intermuscular adipose tissue and metabolic associations in HIV infection.

Obesity (Silver Spring, Md.)

Scherzer R, Shen W, Heymsfield SB, Lewis CE, Kotler DP, Punyanitya M, Bacchetti P, Shlipak MG, Grunfeld C

Effect of inter-reader variability on outcomes in studies using carotid intima media thickness quantified by carotid ultrasonography.

European journal of epidemiology

Delaney JA, Scherzer R, Polak J, Biggs ML, Kronmal R, Chen H, Sidney S, Grunfeld C

A genome-wide association study of carotid atherosclerosis in HIV-infected men.

AIDS (London, England)

Shrestha S, Irvin MR, Taylor KD, Wiener HW, Pajewski NM, Haritunians T, Delaney JA, Schambelan M, Polak JF, Arnett DK, Chen YD, Grunfeld C

Association between kidney function and albuminuria with cardiovascular events in HIV-infected persons.

Circulation

Choi AI, Li Y, Deeks SG, Grunfeld C, Volberding PA, Shlipak MG

Relation of coronary artery plaque location to extent of coronary artery disease studied by computed tomographic angiography.

Journal of cardiovascular computed tomography

Grunfeld C, Scherzer R, Varosy PD, Ambarish G, Nasir K, Budoff M

The protease inhibitor combination lopinavir/ritonavir does not decrease insulin secretion in healthy, HIV-seronegative volunteers.

AIDS (London, England)

Pao VY, Lee GA, Taylor S, Aweeka FT, Schwarz JM, Mulligan K, Schambelan M, Grunfeld C

The acute phase response inhibits reverse cholesterol transport.

Journal of lipid research

Feingold KR, Grunfeld C

Association of HIV infection, demographic and cardiovascular risk factors with all-cause mortality in the recent HAART era.

Journal of acquired immune deficiency syndromes (1999)

Cockerham L, Scherzer R, Zolopa A, Rimland D, Lewis CE, Bacchetti P, Grunfeld C, Shlipak M, Tien PC

The acute phase response stimulates the expression of angiopoietin like protein 4.

Biochemical and biophysical research communications

Lu B, Moser A, Shigenaga JK, Grunfeld C, Feingold KR

The acute effects of HIV protease inhibitors on insulin suppression of glucose production in healthy HIV-negative men.

Journal of acquired immune deficiency syndromes (1999)

Lee GA, Schwarz JM, Patzek S, Kim S, Dyachenko A, Wen M, Mulligan K, Schambelan M, Grunfeld C

Preclinical atherosclerosis due to HIV infection: carotid intima-medial thickness measurements from the FRAM study.

AIDS (London, England)

Grunfeld C, Delaney JA, Wanke C, Currier JS, Scherzer R, Biggs ML, Tien PC, Shlipak MG, Sidney S, Polak JF, O'Leary D, Bacchetti P, Kronmal RA

ADRP/ADFP and Mal1 expression are increased in macrophages treated with TLR agonists.

Atherosclerosis

Feingold KR, Kazemi MR, Magra AL, McDonald CM, Chui LG, Shigenaga JK, Patzek SM, Chan ZW, Londos C, Grunfeld C

The effect of individual antiretroviral drugs on body composition in HIV-infected persons initiating highly active antiretroviral therapy.

Journal of acquired immune deficiency syndromes (1999)

Shlay JC, Sharma S, Peng G, Gibert CL, Grunfeld C

HIV viremia and changes in kidney function.

AIDS (London, England)

Longenecker CT, Scherzer R, Bacchetti P, Lewis CE, Grunfeld C, Shlipak MG

Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm.

Journal of lipid research

Feingold KR, Moser A, Patzek SM, Shigenaga JK, Grunfeld C

Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes.

The Journal of biological chemistry

Jiang YJ, Uchida Y, Lu B, Kim P, Mao C, Akiyama M, Elias PM, Holleran WM, Grunfeld C, Feingold KR

The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia.

The Journal of clinical endocrinology and metabolism

Mulligan K, Khatami H, Schwarz JM, Sakkas GK, DePaoli AM, Tai VW, Wen MJ, Lee GA, Grunfeld C, Schambelan M

Racial differences in changes of metabolic parameters and body composition in antiretroviral therapy-naive persons initiating antiretroviral therapy.

Journal of acquired immune deficiency syndromes (1999)

Gibert CL, Shlay JC, Sharma S, Bartsch G, Peng G, Grunfeld C

Endotoxin in the gut and chylomicrons: translocation or transportation?

Journal of lipid research

Grunfeld C, Feingold KR

LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes.

American journal of physiology. Endocrinology and metabolism

Lu B, Lu Y, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR

Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjects.

The American journal of clinical nutrition

Scherzer R, Shen W, Bacchetti P, Kotler D, Lewis CE, Shlipak MG, Punyanitya M, Heymsfield SB, Grunfeld C

Understanding the complications of antiretroviral drugs.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Grunfeld C

Inflammation stimulates the expression of PCSK9.

Biochemical and biophysical research communications

Feingold KR, Moser AH, Shigenaga JK, Patzek SM, Grunfeld C

LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney.

Journal of lipid research

Feingold KR, Wang Y, Moser A, Shigenaga JK, Grunfeld C

Contribution of metabolic and anthropometric abnormalities to cardiovascular disease risk factors.

Circulation

Grunfeld C, Kotler DP, Arnett DK, Falutz JM, Haffner SM, Hruz P, Masur H, Meigs JB, Mulligan K, Reiss P, Samaras K

State of the science conference: Initiative to decrease cardiovascular risk and increase quality of care for patients living with HIV/AIDS: executive summary.

Circulation

Grinspoon SK, Grunfeld C, Kotler DP, Currier JS, Lundgren JD, Dubé MP, Lipshultz SE, Hsue PY, Squires K, Schambelan M, Wilson PW, Yarasheski KE, Hadigan CM, Stein JH, Eckel RH

Association of HIV infection and HIV/HCV coinfection with C-reactive protein levels: the fat redistribution and metabolic change in HIV infection (FRAM) study.

Journal of acquired immune deficiency syndromes (1999)

Reingold J, Wanke C, Kotler D, Lewis C, Tracy R, Heymsfield S, Tien P, Bacchetti P, Scherzer R, Grunfeld C, Shlipak M

Insulin resistance in HIV infection: drugs, host responses, or restoration to health?

Topics in HIV medicine : a publication of the International AIDS Society, USA

Grunfeld C

Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects.

The American journal of clinical nutrition

Scherzer R, Shen W, Bacchetti P, Kotler D, Lewis CE, Shlipak MG, Heymsfield SB, Grunfeld C

HDL and innate immunity: a tale of two apolipoproteins.

Journal of lipid research

Grunfeld C, Feingold KR

Long-term subcutaneous tissue changes among antiretroviral-naive persons initiating stavudine, zidovudine, or abacavir with lamivudine.

Journal of acquired immune deficiency syndromes (1999)

Shlay JC, Sharma S, Peng G, Gibert CL, Grunfeld C

The associations of regional adipose tissue with lipid and lipoprotein levels in HIV-infected men.

Journal of acquired immune deficiency syndromes (1999)

Wohl D, Scherzer R, Heymsfield S, Simberkoff M, Sidney S, Bacchetti P, Grunfeld C

Association of antiretroviral therapy with fibrinogen levels in HIV-infection.

AIDS (London, England)

Madden E, Lee G, Kotler DP, Wanke C, Lewis CE, Tracy R, Heymsfield S, Shlipak MG, Bacchetti P, Scherzer R, Grunfeld C

HIV therapy, metabolic syndrome, and cardiovascular risk.

Current atherosclerosis reports

Pao V, Lee GA, Grunfeld C

Illicit drug use and HIV treatment outcomes in a US cohort.

AIDS (London, England)

Cofrancesco J, Scherzer R, Tien PC, Gibert CL, Southwell H, Sidney S, Dobs A, Grunfeld C

Infection and inflammation decrease apolipoprotein M expression.

Atherosclerosis

Feingold KR, Shigenaga JK, Chui LG, Moser A, Khovidhunkit W, Grunfeld C

Cystatin C level as a marker of kidney function in human immunodeficiency virus infection: the FRAM study.

Archives of internal medicine

Odden MC, Scherzer R, Bacchetti P, Szczech LA, Sidney S, Grunfeld C, Shlipak MG

Association of upper trunk and visceral adipose tissue volume with insulin resistance in control and HIV-infected subjects in the FRAM study.

Journal of acquired immune deficiency syndromes (1999)

Grunfeld C, Rimland D, Gibert CL, Powderly WG, Sidney S, Shlipak MG, Bacchetti P, Scherzer R, Haffner S, Heymsfield SB

Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteers.

AIDS (London, England)

Lee GA, Rao M, Mulligan K, Lo JC, Aweeka F, Schwarz JM, Schambelan M, Grunfeld C

Relationship of fat distribution with adipokines in human immunodeficiency virus infection.

The Journal of clinical endocrinology and metabolism

Kosmiski LA, Bacchetti P, Kotler DP, Heymsfield SB, Lewis CE, Shlipak MG, Scherzer R, Grunfeld C

Prevalence and factors associated with dry skin in HIV infection: the FRAM study.

AIDS (London, England)

Lee D, Benson CA, Lewis CE, Grunfeld C, Scherzer R

Recombinant human growth hormone to treat HIV-associated adipose redistribution syndrome: 12 week induction and 24-week maintenance therapy.

Journal of acquired immune deficiency syndromes (1999)

Grunfeld C, Thompson M, Brown SJ, Richmond G, Lee D, Muurahainen N, Kotler DP

Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response.

Biochimica et biophysica acta

Lu B, Sims PJ, Wiedmer T, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR

Microalbuminuria in HIV infection.

AIDS (London, England)

Szczech LA, Grunfeld C, Scherzer R, Canchola JA, van der Horst C, Sidney S, Wohl D, Shlipak MG

Long-term body composition and metabolic changes in antiretroviral naive persons randomized to protease inhibitor-, nonnucleoside reverse transcriptase inhibitor-, or protease inhibitor plus nonnucleoside reverse transcriptase inhibitor-based strategy.

Journal of acquired immune deficiency syndromes (1999)

Shlay JC, Bartsch G, Peng G, Wang J, Grunfeld C, Gibert CL, Visnegarwala F, Raghavan SS, Xiang Y, Farrough M, Perry HE, Kotler D, El-Sadr WM

Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells.

Metabolism: clinical and experimental

Kim MS, Sweeney TR, Shigenaga JK, Chui LG, Moser A, Grunfeld C, Feingold KR

Effects of growth hormone on visceral adipose tissue and dyslipidemia in HIV, an erratum.

Journal of acquired immune deficiency syndromes (1999)

Kotler DP, Muurahainen N, Grunfeld C, Wanke C, Thompson M, Saag M, Bock D, Simons G, Gertner JM

Single-dose lopinavir-ritonavir acutely inhibits insulin-mediated glucose disposal in healthy volunteers.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Lee GA, Lo JC, Aweeka F, Schwarz JM, Mulligan K, Schambelan M, Grunfeld C

Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response.

Journal of lipid research

Lu B, Moser AH, Shigenaga JK, Feingold KR, Grunfeld C

Waist circumference correlates with metabolic syndrome indicators better than percentage fat.

Obesity (Silver Spring, Md.)

Shen W, Punyanitya M, Chen J, Gallagher D, Albu J, Pi-Sunyer X, Lewis CE, Grunfeld C, Heshka S, Heymsfield SB

Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1).

Journal of lipid research

Lu B, Xu FY, Jiang YJ, Choy PC, Hatch GM, Grunfeld C, Feingold KR

The study of fat redistribution and metabolic change in HIV infection (FRAM): methods, design, and sample characteristics.

American journal of epidemiology

Tien PC, Benson C, Zolopa AR, Sidney S, Osmond D, Grunfeld C

Oxandrolone in the treatment of HIV-associated weight loss in men: a randomized, double-blind, placebo-controlled study.

Journal of acquired immune deficiency syndromes (1999)

Grunfeld C, Kotler DP, Dobs A, Glesby M, Bhasin S

Decreased nuclear hormone receptor expression in the livers of mice in late pregnancy.

American journal of physiology. Endocrinology and metabolism

Sweeney TR, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR

Fish oil for treatment of hypertriglyceridemia in HIV infection: fish or foul?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Grunfeld C

Fat distribution in men with HIV infection.

Journal of acquired immune deficiency syndromes (1999)

Bacchetti P, Gripshover B, Grunfeld C, Heymsfield S, McCreath H, Osmond D, Saag M, Scherzer R, Shlipak M, Tien P

Sex differences in the associations of HIV disease characteristics and body composition in antiretroviral-naive persons.

The American journal of clinical nutrition

Visnegarwala F, Raghavan SS, Mullin CM, Bartsch G, Wang J, Kotler D, Gibert CL, Shlay J, Grunfeld C, Carr A, El-Sadr W

Downregulation of liver X receptor-alpha in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines.

Journal of lipid research

Wang Y, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR

Suppression of estrogen-related receptor alpha and medium-chain acyl-coenzyme A dehydrogenase in the acute-phase response.

Journal of lipid research

Kim MS, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C

Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by toll-like receptor agonists.

Arteriosclerosis, thrombosis, and vascular biology

Kazemi MR, McDonald CM, Shigenaga JK, Grunfeld C, Feingold KR

Body composition and metabolic changes in antiretroviral-naive patients randomized to didanosine and stavudine vs. abacavir and lamivudine.

Journal of acquired immune deficiency syndromes (1999)

Shlay JC, Visnegarwala F, Bartsch G, Wang J, Peng G, El-Sadr WM, Gibert C, Kotler D, Grunfeld C, Raghavan S

The effects of HIV protease inhibitors on carbohydrate and lipid metabolism.

Current HIV/AIDS reports

Lee GA, Rao MN, Grunfeld C

Parotid secretory protein is an HDL-associated protein with anticandidal activity.

American journal of physiology. Regulatory, integrative and comparative physiology

Khovidhunkit W, Hachem JP, Medzihradszky KF, Duchateau PN, Shigenaga JK, Moser AH, Movsesyan I, Naya-Vigne J, Kane JP, Feingold KR, Grunfeld C

The Effects of HIV Protease Inhibitors on Carbohydrate and Lipid Metabolism.

Current infectious disease reports

Lee GA, Rao MN, Grunfeld C

Indinavir increases glucose production in healthy HIV-negative men.

AIDS (London, England)

Schwarz JM, Lee GA, Park S, Noor MA, Lee J, Wen M, Lo JC, Mulligan K, Schambelan M, Grunfeld C

Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL.

Atherosclerosis

Khovidhunkit W, Duchateau PN, Medzihradszky KF, Moser AH, Naya-Vigne J, Shigenaga JK, Kane JP, Grunfeld C, Feingold KR

Development of multiple lipomas during treatment with rosiglitazone in a patient with HIV-associated lipoatrophy.

AIDS (London, England)

Mafong DD, Lee GA, Yu S, Tien P, Mauro T, Grunfeld C

The effects of low-dose growth hormone in HIV-infected men with fat accumulation: a pilot study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Lo JC, Mulligan K, Noor MA, Lee GA, Schwarz JM, Grunfeld C, Schambelan M

Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response.

American journal of physiology. Endocrinology and metabolism

Kim MS, Shigenaga J, Moser A, Grunfeld C, Feingold KR

HIV protease inhibitors increase adiponectin levels in HIV-negative men.

Journal of acquired immune deficiency syndromes (1999)

Lee GA, Mafong DD, Noor MA, Lo JC, Mulligan K, Schwarz JM, Schambelan M, Grunfeld C

Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.

Journal of lipid research

Khovidhunkit W, Kim MS, Memon RA, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C

The metabolic effects of lopinavir/ritonavir in HIV-negative men.

AIDS (London, England)

Lee GA, Seneviratne T, Noor MA, Lo JC, Schwarz JM, Aweeka FT, Mulligan K, Schambelan M, Grunfeld C

Effects of growth hormone on abnormal visceral adipose tissue accumulation and dyslipidemia in HIV-infected patients.

Journal of acquired immune deficiency syndromes (1999)

Kotler DP, Muurahainen N, Grunfeld C, Wanke C, Thompson M, Saag M, Bock D, Simons G, Gertner JM

Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response.

American journal of physiology. Endocrinology and metabolism

Feingold K, Kim MS, Shigenaga J, Moser A, Grunfeld C

What is HIV-associated lipodystrophy? Defining fat distribution changes in HIV infection.

Current opinion in infectious diseases

Tien PC, Grunfeld C

Incidence of lipoatrophy and lipohypertrophy in the women's interagency HIV study.

Journal of acquired immune deficiency syndromes (1999)

Tien PC, Cole SR, Williams CM, Li R, Justman JE, Cohen MH, Young M, Rubin N, Augenbraun M, Grunfeld C

Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR.

Journal of lipid research

Khovidhunkit W, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR

Repression of farnesoid X receptor during the acute phase response.

The Journal of biological chemistry

Kim MS, Shigenaga J, Moser A, Feingold K, Grunfeld C

Difficulties in understanding the metabolic complications of acquired immune deficiency syndrome.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Grunfeld C, Tien P

Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: recommendations of an International AIDS Society-USA panel.

Journal of acquired immune deficiency syndromes (1999)

Schambelan M, Benson CA, Carr A, Currier JS, Dubé MP, Gerber JG, Grinspoon SK, Grunfeld C, Kotler DP, Mulligan K, Powderly WG, Saag MS

Simvastatin-nelfinavir interaction implicated in rhabdomyolysis and death.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Hare CB, Vu MP, Grunfeld C, Lampiris HW

Sick euthyroid syndrome is associated with decreased TR expression and DNA binding in mouse liver.

American journal of physiology. Endocrinology and metabolism

Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR

Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol.

Hepatology (Baltimore, Md.)

Monto A, Alonzo J, Watson JJ, Grunfeld C, Wright TL

Altered gene expressions involved in energy expenditure in 5-HT(2C) receptor mutant mice.

Biochemical and biophysical research communications

Nonogaki K, Memon RA, Grunfeld C, Feingold KR, Tecott LH

Leptin and the immunosuppression of malnutrition.

The Journal of clinical endocrinology and metabolism

Grunfeld C

HIV protease inhibitors and glucose metabolism.

AIDS (London, England)

Grunfeld C

Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled study.

AIDS (London, England)

Noor MA, Seneviratne T, Aweeka FT, Lo JC, Schwarz JM, Mulligan K, Schambelan M, Grunfeld C

Effects of recombinant human growth hormone on hepatic lipid and carbohydrate metabolism in HIV-infected patients with fat accumulation.

The Journal of clinical endocrinology and metabolism

Schwarz JM, Mulligan K, Lee J, Lo JC, Wen M, Noor MA, Grunfeld C, Schambelan M

The fatty liver in AIDS.

Seminars in gastrointestinal disease

Tien PC, Grunfeld C

Leptin regulation of the immune response and the immunodeficiency of malnutrition.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Faggioni R, Feingold KR, Grunfeld C

Regulation of scavenger receptor class B type I in hamster liver and Hep3B cells by endotoxin and cytokines.

Journal of lipid research

Khovidhunkit W, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR

The effects of recombinant human growth hormone on body composition and glucose metabolism in HIV-infected patients with fat accumulation.

The Journal of clinical endocrinology and metabolism

Lo JC, Mulligan K, Noor MA, Schwarz JM, Halvorsen RA, Grunfeld C, Schambelan M

Cholesterol efflux by acute-phase high density lipoprotein: role of lecithin: cholesterol acyltransferase.

Journal of lipid research

Khovidhunkit W, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C

Metabolic effects of indinavir in healthy HIV-seronegative men.

AIDS (London, England)

Noor MA, Lo JC, Mulligan K, Schwarz JM, Halvorsen RA, Schambelan M, Grunfeld C

Regulation of sphingolipid and glycosphingolipid metabolism in extrahepatic tissues by endotoxin.

Journal of lipid research

Memon RA, Holleran WM, Uchida Y, Moser AH, Grunfeld C, Feingold KR

Infection and inflammation induce LDL oxidation in vivo.

Arteriosclerosis, thrombosis, and vascular biology

Memon RA, Staprans I, Noor M, Holleran WM, Uchida Y, Moser AH, Feingold KR, Grunfeld C

Infection and inflammation-induced proatherogenic changes of lipoproteins.

The Journal of infectious diseases

Khovidhunkit W, Memon RA, Feingold KR, Grunfeld C

The acute phase response is associated with retinoid X receptor repression in rodent liver.

The Journal of biological chemistry

Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR

Reduced leptin levels in starvation increase susceptibility to endotoxic shock.

The American journal of pathology

Faggioni R, Moser A, Feingold KR, Grunfeld C

Oxidized cholesterol in the diet accelerates the development of atherosclerosis in LDL receptor- and apolipoprotein E-deficient mice.

Arteriosclerosis, thrombosis, and vascular biology

Staprans I, Pan XM, Rapp JH, Grunfeld C, Feingold KR

Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18.

Proceedings of the National Academy of Sciences of the United States of America

Faggioni R, Jones-Carson J, Reed DA, Dinarello CA, Feingold KR, Grunfeld C, Fantuzzi G

Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-alpha.

Biochimica et biophysica acta

Memon RA, Hotamisligil GS, Wiesbrock SM, Uysal KT, Faggioni R, Moser AH, Feingold KR, Grunfeld C

Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection.

Journal of acquired immune deficiency syndromes (1999)

Mulligan K, Grunfeld C, Tai VW, Algren H, Pang M, Chernoff DN, Lo JC, Schambelan M

Plasma platelet-activating factor acetylhydrolase activity in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.

Metabolism: clinical and experimental

Khovidhunkit W, Memon RA, Shigenaga JK, Pang M, Schambelan M, Mulligan K, Feingold KR, Grunfeld C

Down-regulation of liver and heart specific fatty acid binding proteins by endotoxin and cytokines in vivo.

Biochimica et biophysica acta

Memon RA, Bass NM, Moser AH, Fuller J, Appel R, Grunfeld C, Feingold KR

Regulation of glycosphingolipid metabolism in liver during the acute phase response.

The Journal of biological chemistry

Memon RA, Holleran WM, Uchida Y, Moser AH, Ichikawa S, Hirabayashi Y, Grunfeld C, Feingold KR

In vivo regulation of plasma platelet-activating factor acetylhydrolase during the acute phase response.

The American journal of physiology

Memon RA, Fuller J, Moser AH, Feingold KR, Grunfeld C

Endotoxin and interleukin-1 decrease hepatic lipase mRNA levels.

Atherosclerosis

Feingold KR, Memon RA, Moser AH, Shigenaga JK, Grunfeld C

Lipoproteins inhibit macrophage activation by lipoteichoic acid.

Journal of lipid research

Grunfeld C, Marshall M, Shigenaga JK, Moser AH, Tobias P, Feingold KR

Leptin deficiency enhances sensitivity to endotoxin-induced lethality.

The American journal of physiology

Faggioni R, Fantuzzi G, Gabay C, Moser A, Dinarello CA, Feingold KR, Grunfeld C

Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin.

Arteriosclerosis, thrombosis, and vascular biology

Memon RA, Holleran WM, Moser AH, Seki T, Uchida Y, Fuller J, Shigenaga JK, Grunfeld C, Feingold KR

In vivo regulation of acyl-CoA synthetase mRNA and activity by endotoxin and cytokines.

The American journal of physiology

Memon RA, Fuller J, Moser AH, Smith PJ, Feingold KR, Grunfeld C

Regulation of microsomal triglyceride transfer protein mRNA expression by endotoxin and cytokines.

Journal of lipid research

Navasa M, Gordon DA, Hariharan N, Jamil H, Shigenaga JK, Moser A, Fiers W, Pollock A, Grunfeld C, Feingold KR

Induction of UCP2 gene expression by LPS: a potential mechanism for increased thermogenesis during infection.

Biochemical and biophysical research communications

Faggioni R, Shigenaga J, Moser A, Feingold KR, Grunfeld C

Regulation of fatty acid transport protein and fatty acid translocase mRNA levels by endotoxin and cytokines.

The American journal of physiology

Memon RA, Feingold KR, Moser AH, Fuller J, Grunfeld C

Beneficial effects of cytokine induced hyperlipidemia.

Zeitschrift fur Ernahrungswissenschaft

Feingold KR, Hardardóttir I, Grunfeld C

IL-1 beta mediates leptin induction during inflammation.

The American journal of physiology

Faggioni R, Fantuzzi G, Fuller J, Dinarello CA, Feingold KR, Grunfeld C

Lipoproteins: are they important components of host defense?

Hepatology (Baltimore, Md.)

Feingold KR, Grunfeld C

Permeability barrier disruption coordinately regulates mRNA levels for key enzymes of cholesterol, fatty acid, and ceramide synthesis in the epidermis.

The Journal of investigative dermatology

Harris IR, Farrell AM, Grunfeld C, Holleran WM, Elias PM, Feingold KR

Abnormalities of apolipoprotein E in the acquired immunodeficiency syndrome.

The Journal of clinical endocrinology and metabolism

Grunfeld C, Doerrler W, Pang M, Jensen P, Weisgraber KH, Feingold KR

Endotoxin, tumor necrosis factor, and interleukin-1 decrease hepatic squalene synthase activity, protein, and mRNA levels in Syrian hamsters.

Journal of lipid research

Memon RA, Shechter I, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR

Barrier disruption increases gene expression of cytokines and the 55 kD TNF receptor in murine skin.

Experimental dermatology

Wood LC, Stalder AK, Liou A, Campbell IL, Grunfeld C, Elias PM, Feingold KR

Recombinant human growth hormone in patients with HIV-associated wasting. A randomized, placebo-controlled trial. Serostim Study Group.

Annals of internal medicine

Schambelan M, Mulligan K, Grunfeld C, Daar ES, LaMarca A, Kotler DP, Wang J, Bozzette SA, Breitmeyer JB

Serum leptin levels in the acquired immunodeficiency syndrome.

The Journal of clinical endocrinology and metabolism

Grunfeld C, Pang M, Shigenaga JK, Jensen P, Lallone R, Friedman J, Feingold KR

LIF and CNTF, which share the gp130 transduction system, stimulate hepatic lipid metabolism in rats.

The American journal of physiology

Nonogaki K, Pan XM, Moser AH, Shigenaga J, Staprans I, Sakamoto N, Grunfeld C, Feingold KR

Soluble (1-->3)-beta-D-glucan purified from Candida albicans: biologic effects and distribution in blood and organs in rabbits.

The Journal of laboratory and clinical medicine

Yoshida M, Roth RI, Grunfeld C, Feingold KR, Levin J

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.

The Journal of clinical investigation

Grunfeld C, Zhao C, Fuller J, Pollack A, Moser A, Friedman J, Feingold KR

Growth hormone replacement in healthy older men improves body composition but not functional ability.

Annals of internal medicine

Papadakis MA, Grady D, Black D, Tierney MJ, Gooding GA, Schambelan M, Grunfeld C

Barrier disruption stimulates interleukin-1 alpha expression and release from a pre-formed pool in murine epidermis.

The Journal of investigative dermatology

Wood LC, Elias PM, Calhoun C, Tsai JC, Grunfeld C, Feingold KR

Beta-nerve growth factor as a mediator of the acute phase response in vivo.

Biochemical and biophysical research communications

Nonogaki K, Moser AH, Shigenaga J, Feingold KR, Grunfeld C

Endotoxin, TNF, and IL-1 decrease cholesterol 7 alpha-hydroxylase mRNA levels and activity.

Journal of lipid research

Feingold KR, Spady DK, Pollock AS, Moser AH, Grunfeld C

Regulation of lipid metabolism by cytokines during host defense.

Nutrition (Burbank, Los Angeles County, Calif.)

Grunfeld C, Feingold KR

Insulin-like growth factor 1 and functional status in healthy older men.

Journal of the American Geriatrics Society

Papadakis MA, Grady D, Tierney MJ, Black D, Wells L, Grunfeld C

Effects of endotoxin on lipid metabolism.

Biochemical Society transactions

Hardardóttir I, Grunfeld C, Feingold KR

Keratinocyte growth factor increases fatty acid mobilization and hepatic triglyceride secretion in rats.

Endocrinology

Nonogaki K, Pan XM, Moser AH, Staprans I, Feingold KR, Grunfeld C

Lipoteichoic acid stimulates lipolysis and hepatic triglyceride secretion in rats in vivo.

Journal of lipid research

Nonogaki K, Moser AH, Pan XM, Staprans I, Grunfeld C, Feingold KR

Endotoxin induces parathyroid hormone-related protein gene expression in splenic stromal and smooth muscle cells, not in splenic lymphocytes.

Endocrinology

Funk JL, Lausier J, Moser AH, Shigenaga JK, Huling S, Nissenson RA, Strewler GJ, Grunfeld C, Feingold KR

Discordant regulation of proteins of cholesterol metabolism during the acute phase response.

Journal of lipid research

Feingold KR, Pollock AS, Moser AH, Shigenaga JK, Grunfeld C

Triglyceride-rich lipoproteins prevent septic death in rats.

The Journal of experimental medicine

Read TE, Grunfeld C, Kumwenda ZL, Calhoun MC, Kane JP, Feingold KR, Rapp JH

Endotoxin and TNF lead to reduced plasma LCAT activity and decreased hepatic LCAT mRNA levels in Syrian hamsters.

Journal of lipid research

Ly H, Francone OL, Fielding CJ, Shigenaga JK, Moser AH, Grunfeld C, Feingold KR

State of the art in wasting: an interview with Carl Grunfeld, PhD. Interview by Jeff Getty.

BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation

Grunfeld C

Interleukin-6 stimulates hepatic triglyceride secretion in rats.

Endocrinology

Nonogaki K, Fuller GM, Fuentes NL, Moser AH, Staprans I, Grunfeld C, Feingold KR

Role for circulating lipoproteins in protection from endotoxin toxicity.

Infection and immunity

Feingold KR, Funk JL, Moser AH, Shigenaga JK, Rapp JH, Grunfeld C

Cutaneous permeability barrier disruption increases fatty acid synthetic enzyme activity in the epidermis of hairless mice.

The Journal of investigative dermatology

Ottey KA, Wood LC, Grunfeld C, Elias PM, Feingold KR

Triglyceride-rich lipoproteins improve survival when given after endotoxin in rats.

Surgery

Read TE, Grunfeld C, Kumwenda Z, Calhoun MC, Kane JP, Feingold KR, Rapp JH

Occlusion lowers cytokine mRNA levels in essential fatty acid-deficient and normal mouse epidermis, but not after acute barrier disruption.

The Journal of investigative dermatology

Wood LC, Elias PM, Sequeira-Martin SM, Grunfeld C, Feingold KR

Effect of endotoxin and cytokines on lipoprotein lipase activity in mice.

Arteriosclerosis and thrombosis : a journal of vascular biology

Feingold KR, Marshall M, Gulli R, Moser AH, Grunfeld C

Leukemia inhibitory factor induces changes in lipid metabolism in cultured adipocytes.

Endocrinology

Marshall MK, Doerrler W, Feingold KR, Grunfeld C

Barrier function coordinately regulates epidermal IL-1 and IL-1 receptor antagonist mRNA levels.

Experimental dermatology

Wood LC, Feingold KR, Sequeira-Martin SM, Elias PM, Grunfeld C

Diabetes increases hepatic hydroxymethyl glutaryl coenzyme A reductase protein and mRNA levels in the small intestine.

Metabolism: clinical and experimental

Feingold KR, Wilson DE, Wood LC, Kwong LK, Moser AH, Grunfeld C

Fatty acid synthesis in obese insulin resistant diabetic mice.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

Memon RA, Grunfeld C, Moser AH, Feingold KR

Permeability barrier disruption alters the localization and expression of TNF alpha/protein in the epidermis.

Archives of dermatological research

Tsai JC, Feingold KR, Crumrine D, Wood LC, Grunfeld C, Elias PM

Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoproteins in Syrian hamsters.

Journal of lipid research

Feingold KR, Hardardottir I, Memon R, Krul EJ, Moser AH, Taylor JM, Grunfeld C

The protective effect of serum lipoproteins against bacterial lipopolysaccharide.

European heart journal

Read TE, Harris HW, Grunfeld C, Feingold KR, Kane JP, Rapp JH

Endotoxin increases parathyroid hormone-related protein mRNA levels in mouse spleen. Mediation by tumor necrosis factor.

The Journal of clinical investigation

Funk JL, Krul EJ, Moser AH, Shigenaga JK, Strewler GJ, Grunfeld C, Feingold KR

Anabolic effects of recombinant human growth hormone in patients with wasting associated with human immunodeficiency virus infection.

The Journal of clinical endocrinology and metabolism

Mulligan K, Grunfeld C, Hellerstein MK, Neese RA, Schambelan M

Indices of thyroid function and weight loss in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.

Metabolism: clinical and experimental

Grunfeld C, Pang M, Doerrler W, Jensen P, Shimizu L, Feingold KR, Cavalieri RR

Chylomicrons enhance endotoxin excretion in bile.

Infection and immunity

Read TE, Harris HW, Grunfeld C, Feingold KR, Calhoun MC, Kane JP, Rapp JH

The hypertriglyceridemia of acquired immunodeficiency syndrome is associated with an increased prevalence of low density lipoprotein subclass pattern B.

The Journal of clinical endocrinology and metabolism

Feingold KR, Krauss RM, Pang M, Doerrler W, Jensen P, Grunfeld C

Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death.

The Journal of clinical investigation

Harris HW, Grunfeld C, Feingold KR, Read TE, Kane JP, Jones AL, Eichbaum EB, Bland GF, Rapp JH

Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance.

Journal of lipid research

Feingold KR, Staprans I, Memon RA, Moser AH, Shigenaga JK, Doerrler W, Dinarello CA, Grunfeld C

LDL subclass phenotypes and triglyceride metabolism in non-insulin-dependent diabetes.

Arteriosclerosis and thrombosis : a journal of vascular biology

Feingold KR, Grunfeld C, Pang M, Doerrler W, Krauss RM

In vivo effects of interferon-alpha and interferon-gamma on lipolysis and ketogenesis.

Endocrinology

Memon RA, Feingold KR, Moser AH, Doerrler W, Grunfeld C

Role of cytokines in inducing hyperlipidemia.

Diabetes

Feingold KR, Grunfeld C

Tissue-specific regulation of insulin receptor mRNA levels in rats with STZ-induced diabetes mellitus.

Diabetes

Sechi LA, Griffin CA, Grady EF, Grunfeld C, Kalinyak JE, Schambelan M

Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice.

The Journal of clinical investigation

Wood LC, Jackson SM, Elias PM, Grunfeld C, Feingold KR

Differential effects of interleukin-1 and tumor necrosis factor on ketogenesis.

The American journal of physiology

Memon RA, Feingold KR, Moser AH, Doerrler W, Adi S, Dinarello CA, Grunfeld C

Metabolic disturbances and wasting in the acquired immunodeficiency syndrome.

The New England journal of medicine

Grunfeld C, Feingold KR

Tumor necrosis factor, interleukin, and interferon induced changes in lipid metabolism as part of host defense.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

Grunfeld C, Feingold KR

Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.

The Journal of clinical endocrinology and metabolism

Grunfeld C, Pang M, Doerrler W, Shigenaga JK, Jensen P, Feingold KR

Role for monokines in the metabolic effects of endotoxin. Interferon-gamma restores responsiveness of C3H/HeJ mice in vivo.

The Journal of clinical investigation

Adi S, Pollock AS, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C

Wasting in the acquired immunodeficiency syndrome.

Seminars in liver disease

Grunfeld C, Kotler DP

Resting energy expenditure, caloric intake, and short-term weight change in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.

The American journal of clinical nutrition

Grunfeld C, Pang M, Shimizu L, Shigenaga JK, Jensen P, Feingold KR

Diabetic foot ulcers: etiology, treatment, and prevention.

Advances in internal medicine

Grunfeld C

Pathophysiology of the AIDS wasting syndrome.

AIDS clinical review

Grunfeld C, Kotler DP

Regulation of hepatic lipid metabolism by cytokines that induce the acute phase response.

Folia histochemica et cytobiologica

Grunfeld C, Memon RA, Rapp JH, Feingold KR

Tumor necrosis factor, cytokines, and the hyperlipidemia of infection.

Trends in endocrinology and metabolism: TEM

Grunfeld C, Feingold KR

Tumor necrosis factor-alpha, interleukin-1, and interferon alpha stimulate triglyceride synthesis in HepG2 cells.

Metabolism: clinical and experimental

Grunfeld C, Dinarello CA, Feingold KR

Effect of interleukin-1 on lipid metabolism in the rat. Similarities to and differences from tumor necrosis factor.

Arteriosclerosis and thrombosis : a journal of vascular biology

Feingold KR, Soued M, Adi S, Staprans I, Neese R, Shigenaga J, Doerrler W, Moser A, Dinarello CA, Grunfeld C

Localization of tumor necrosis factor-stimulated DNA synthesis in the liver.

Hepatology (Baltimore, Md.)

Feingold KR, Barker ME, Jones AL, Grunfeld C

Neutral lipid storage disease: a possible functional defect in phospholipid- linked triacylglycerol metabolism.

Biochimica et biophysica acta

Williams ML, Coleman RA, Placezk D, Grunfeld C

Circulating interferon-alpha levels and hypertriglyceridemia in the acquired immunodeficiency syndrome.

The American journal of medicine

Grunfeld C, Kotler DP, Shigenaga JK, Doerrler W, Tierney A, Wang J, Pierson RN, Feingold KR

The metabolic effects of tumor necrosis factor and other cytokines.

Biotherapy (Dordrecht, Netherlands)

Grunfeld C, Feingold KR

Tumor necrosis factor-increased hepatic very-low-density lipoprotein production and increased serum triglyceride levels in diabetic rats.

Diabetes

Feingold KR, Soued M, Adi S, Staprans I, Shigenaga J, Doerrler W, Moser A, Grunfeld C

Small intestinal fatty acid synthesis is increased in diabetic rats.

Endocrinology

Feingold KR, Moser A, Adi S, Soued M, Grunfeld C

Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice.

The Journal of clinical investigation

Harris HW, Grunfeld C, Feingold KR, Rapp JH

Diet affects the mechanisms by which TNF stimulates hepatic triglyceride production.

The American journal of physiology

Feingold KR, Adi S, Staprans I, Moser AH, Neese R, Verdier JA, Doerrler W, Grunfeld C

Search for mediators of the lipogenic effects of tumor necrosis factor: potential role for interleukin 6.

Cancer research

Grunfeld C, Adi S, Soued M, Moser A, Fiers W, Feingold KR

The effect of diet on tumor necrosis factor stimulation of hepatic lipogenesis.

Metabolism: clinical and experimental

Feingold KR, Soued M, Serio MK, Adi S, Moser AH, Grunfeld C

Multiple cytokines stimulate hepatic lipid synthesis in vivo.

Endocrinology

Feingold KR, Soued M, Serio MK, Moser AH, Dinarello CA, Grunfeld C

Tumor necrosis factor stimulates hepatic lipid synthesis and secretion.

Endocrinology

Feingold KR, Serio MK, Adi S, Moser AH, Grunfeld C

Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemia.

The Journal of clinical investigation

Feingold KR, Soued M, Staprans I, Gavin LA, Donahue ME, Huang BJ, Moser AH, Gulli R, Grunfeld C

Effect of tumor necrosis factor administration in vivo on lipoprotein lipase activity in various tissues of the rat.

Journal of lipid research

Grunfeld C, Gulli R, Moser AH, Gavin LA, Feingold KR

Hypertriglyceridemia in the acquired immunodeficiency syndrome.

The American journal of medicine

Grunfeld C, Kotler DP, Hamadeh R, Tierney A, Wang J, Pierson RN

Prevalence of foot pathology and lower extremity complications in a diabetic outpatient clinic.

Journal of rehabilitation research and development

Holewski JJ, Moss KM, Stess RM, Graf PM, Grunfeld C

The acute effects of human growth hormone administration on thyroid function in normal men.

The Journal of clinical endocrinology and metabolism

Grunfeld C, Sherman BM, Cavalieri RR

Mechanisms by which tumor necrosis factor stimulates hepatic fatty acid synthesis in vivo.

Journal of lipid research

Grunfeld C, Verdier JA, Neese R, Moser AH, Feingold KR

Tumor necrosis factor stimulates DNA synthesis in the liver of intact rats.

Biochemical and biophysical research communications

Feingold KR, Soued M, Grunfeld C

Aesthesiometry: quantification of cutaneous pressure sensation in diabetic peripheral neuropathy.

Journal of rehabilitation research and development

Holewski JJ, Stess RM, Graf PM, Grunfeld C

Neutral lipid storage disease with ichthyosis: lipid content and metabolism of fibroblasts.

Journal of inherited metabolic disease

Williams ML, Monger DJ, Rutherford SL, Hincenbergs M, Rehfeld SJ, Grunfeld C