Christian Vaisse, MD, PhD

Professor
Diabetes Center
+1 415 514-0530
Publications: 

Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight.

The Journal of clinical investigation

Wang Y, Bernard A, Comblain F, Yue X, Paillart C, Zhang S, Reiter JF, Vaisse C

OR04-01 MRAP2 Regulates Energy Homeostasis by Promoting Primary Cilia Localization of MC4R.

Journal of the Endocrine Society

Adelaide A Bernard, Irene Ojeda Naharros, Florence Bourgain Guglielmetti, Xinyu Yue, Christian Vaisse

Detailed 3-dimensional body shape features predict body composition, blood metabolites, and functional strength: the Shape Up! studies.

The American journal of clinical nutrition

Ng BK, Sommer MJ, Wong MC, Pagano I, Nie Y, Fan B, Kennedy S, Bourgeois B, Kelly N, Liu YE, Hwaung P, Garber AK, Chow D, Vaisse C, Curless B, Heymsfield SB, Shepherd JA

CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.

Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N

Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation.

Nature metabolism

Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N

CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.

Science (New York, N.Y.)

Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.

Nature genetics

Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C

Cilia and Obesity.

Cold Spring Harbor perspectives in biology

Vaisse C, Reiter JF, Berbari NF

Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.

Cell reports

Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW

The Association of Serum Leptin with Mortality in Older Adults.

PloS one

Mishra S, Harris TB, Hsueh WC, Hue T, Leak TS, Li R, Mehta M, Vaisse C, Sahyoun NR

Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.

PloS one

Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C

Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.

Obesity (Silver Spring, Md.)

Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR

Functional characterization of SIM1-associated enhancers.

Human molecular genetics

Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N

The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus.

International journal of obesity (2005)

Aslan IR, Ranadive SA, Valle I, Kollipara S, Noble JA, Vaisse C

Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.

Nature chemical biology

Ersoy BA, Pardo L, Zhang S, Thompson DA, Millhauser G, Govaerts C, Vaisse C

Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations.

Obesity surgery

Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C

Replication and extension of association between common genetic variants in SIM1 and human adiposity.

Obesity (Silver Spring, Md.)

Swarbrick MM, Evans DS, Valle MI, Favre H, Wu SH, Njajou OT, Li R, Zmuda JM, Miljkovic I, Harris TB, Kwok PY, Vaisse C, Hsueh WC

Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO

Bariatric surgery in a patient with complete MC4R deficiency.

International journal of obesity (2005)

Aslan IR, Ranadive SA, Ersoy BA, Rogers SJ, Lustig RH, Vaisse C

Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity.

Bone

Ionova-Martin SS, Do SH, Barth HD, Szadkowska M, Porter AE, Ager JW, Ager JW, Alliston T, Vaisse C, Ritchie RO

In silico mutagenesis: a case study of the melanocortin 4 receptor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B

Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus.

Clinical endocrinology

Ranadive SA, Ersoy B, Favre H, Cheung CC, Rosenthal SM, Miller WL, Vaisse C

Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study.

Human molecular genetics

Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C

Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene.

The Journal of clinical endocrinology and metabolism

Clément K, Dubern B, Mencarelli M, Czernichow P, Ito S, Wakamatsu K, Barsh GS, Vaisse C, Leger J

Lessons from extreme human obesity: monogenic disorders.

Endocrinology and metabolism clinics of North America

Ranadive SA, Vaisse C

Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain.

Pediatric research

Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K

Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes.

Diabetes, obesity & metabolism

Louet JF, Smith SB, Gautier JF, Molokhia M, Virally ML, Kevorkian JP, Guillausseau PJ, Vexiau P, Charpentier G, German MS, Vaisse C, Urbanek M, Mauvais-Jarvis F

Medical sequencing at the extremes of human body mass.

American journal of human genetics

Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, Dent R, Cohen J, McPherson R, Pennacchio LA

Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating.

The Journal of clinical endocrinology and metabolism

Lubrano-Berthelier C, Dubern B, Lacorte JM, Picard F, Shapiro A, Zhang S, Bertrais S, Hercberg S, Basdevant A, Clement K, Vaisse C

Lack of support for the association between GAD2 polymorphisms and severe human obesity.

PLoS biology

Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson R, Kwok PY, Hinney A, Hebebrand J, Vaisse C

Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function.

Peptides

Govaerts C, Srinivasan S, Shapiro A, Zhang S, Picard F, Clement K, Lubrano-Berthelier C, Vaisse C

High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes.

The Journal of clinical endocrinology and metabolism

Sobngwi E, Gautier JF, Kevorkian JP, Villette JM, Riveline JP, Zhang S, Vexiau P, Leal SM, Vaisse C, Mauvais-Jarvis F

Leptin regulation of bone resorption by the sympathetic nervous system and CART.

Nature

Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G

A statistical approach for array CGH data analysis.

BMC bioinformatics

Picard F, Robin S, Lavielle M, Vaisse C, Daudin JJ

PAX4 gene variations predispose to ketosis-prone diabetes.

Human molecular genetics

Mauvais-Jarvis F, Smith SB, Le May C, Leal SM, Gautier JF, Molokhia M, Riveline JP, Rajan AS, Kevorkian JP, Zhang S, Vexiau P, German MS, Vaisse C

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.

The Journal of clinical investigation

Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C

A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans.

The Journal of clinical endocrinology and metabolism

Lubrano-Berthelier C, Le Stunff C, Bougnères P, Vaisse C

Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance.

Diabetes

Mauvais-Jarvis F, Sobngwi E, Porcher R, Riveline JP, Kevorkian JP, Vaisse C, Charpentier G, Guillausseau PJ, Vexiau P, Gautier JF

The human MC4R promoter: characterization and role in obesity.

Diabetes

Lubrano-Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, Bougneres P, Vaisse C

Emerging trends in the search for genetic variants predisposing to human obesity.

Current opinion in clinical nutrition and metabolic care

Swarbrick MM, Vaisse C

Engineering the melanocortin-4 receptor to control G(s) signaling in vivo.

Annals of the New York Academy of Sciences

Srinivasan S, Vaisse C, Conklin BR

Molecular genetics of human obesity-associated MC4R mutations.

Annals of the New York Academy of Sciences

Lubrano-Berthelier C, Cavazos M, Dubern B, Shapiro A, Stunff CL, Zhang S, Picart F, Govaerts C, Froguel P, Bougneres P, Clement K, Vaisse C

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations.

Human molecular genetics

Lubrano-Berthelier C, Durand E, Dubern B, Shapiro A, Dazin P, Weill J, Ferron C, Froguel P, Vaisse C

Elevated plasma ghrelin levels in Prader Willi syndrome.

Nature medicine

Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS

The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.

Human heredity

Navas MA, Vaisse C, Boger S, Heimesaat M, Kollee LA, Stoffel M

Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass.

Diabetes

Lahlou N, Clement K, Carel JC, Vaisse C, Lotton C, Le Bihan Y, Basdevant A, Lebouc Y, Froguel P, Roger M, Guy-Grand B

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity.

The Journal of clinical investigation

Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P

The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity

Clement K, Hercberg S, Passinge B, Galan P, Varroud-Vial M, Shuldiner AR, Beamer BA, Charpentier G, Guy-Grand B, Froguel P, Vaisse C

Glycodelin: a pane in the implantation window.

Seminars in reproductive medicine

Mueller MD, Vigne JL, Vaisse C, Taylor RN

Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells.

The Journal of clinical endocrinology and metabolism

Taylor RN, Savouret JF, Vaisse C, Vigne JL, Ryan I, Hornung D, Seppälä M, Milgrom E

A frameshift mutation in human MC4R is associated with a dominant form of obesity.

Nature genetics

Vaisse C, Clement K, Guy-Grand B, Froguel P

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.

Nature

Clément K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougnères P, Lebouc Y, Froguel P, Guy-Grand B

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

Nature genetics

Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM

Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes.

Lancet (London, England)

Ruiz J, Blanché H, James RW, Garin MC, Vaisse C, Charpentier G, Cohen N, Morabia A, Passa P, Froguel P

Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.

The New England journal of medicine

Clément K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD

A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus.

Nature genetics

Hager J, Hansen L, Vaisse C, Vionnet N, Philippi A, Poller W, Velho G, Carcassi C, Contu L, Julier C

Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues.

DNA and cell biology

Mellon SH, Kushner JA, Vaisse C

The human placental protein 14 (PP14) gene is localized on chromosome 9q34.

Human genetics

Van Cong N, Vaisse C, Gross MS, Slim R, Milgrom E, Bernheim A

Human placental protein 14 gene: sequence and characterization of a short duplication.

DNA and cell biology

Vaisse C, Atger M, Potier B, Milgrom E

cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells.

Proceedings of the National Academy of Sciences of the United States of America

Mellon SH, Vaisse C