Suneil Koliwad, MD, PhD

Associate Professor in Res
Medicine
+1 415 476-9623

Dr. Suneil Koliwad is an Endocrinologist and an Expert in Diabetes, Obesity, and Metabolism. His lab focuses on the intersection of nutrition, inflammation, and metabolic tissue function in the context of normal physiology, and diseases such as obesity, diabetes, fatty liver disease, and in the course of aging. His group strives to link basic mechanisms of metabolic regulation to causality in clinical patients, and has developed a highly innovative and deeply curated multiethnic obesity cohort at UCSF to assist in achieving this goal.

Publications: 

Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis.

Frontiers in endocrinology

Folick A, Koliwad SK, Valdearcos M

Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.

Proceedings of the National Academy of Sciences of the United States of America

Datta R, Lizama CO, Soltani AK, Mckleroy W, Podolsky MJ, Yang CD, Huynh TL, Cautivo KM, Wang B, Koliwad SK, Abumrad NA, Atabai K

Invariant natural killer T cells coordinate removal of senescent cells.

Med

Shivani Arora, Peter J. Thompson, Yao Wang, Aritra Bhattacharyya, Hara Apostolopoulou, Rachel Hatano, Ram P. Naikawadi, Ajit Shah, Paul J. Wolters, Suneil Koliwad, Mallar Bhattacharya, Anil Bhushan

Blocking Kv1.3 potassium channels psrevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice.

British journal of anaesthesia

Lai LK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.

Cell

Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S

1769-P: Microglial Activation and Inactivation via Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) Alters Peripheral Glucose Homeostasis.

Diabetes

KELLY M. NESS, JOHN DOUGLASS, MARTIN VALDEARCOS-CONTRERAS, MAURICIO D. DORFMAN, ANZELA NIRAULA, SUNEIL K. KOLIWAD, JOSHUA THALER

Neuronal modulation of hepatic lipid accumulation induced by binge-like drinking.

American journal of physiology. Endocrinology and metabolism

Ibars M, Maier MT, Yulyaningsih E, Perez L, Cheang R, Vilhelmsson A, Louie SM, Wegner SA, Yuan X, Eltzschig HK, Hopf FW, Nomura DK, Koliwad SK, Xu AW

Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria.

Nature microbiology

Bess EN, Bisanz JE, Yarza F, Bustion A, Rich BE, Li X, Kitamura S, Waligurski E, Ang QY, Alba DL, Spanogiannopoulos P, Nayfach S, Koliwad SK, Wolan DW, Franke AA, Turnbaugh PJ

Obesity and Fat Metabolism in HIV-infected Individuals: Immunopathogenic Mechanisms and Clinical Implications.

The Journal of infectious diseases

Godfrey C, Bremer A, Alba D, Apovian C, Koethe JR, Koliwad S, Lewis D, Lo J, McComsey GA, Eckard A, Srinivasa S, Trevillyan J, Palmer C, Grinspoon S

mTORC1 to AMPK switching underlies ß-cell metabolic plasticity during maturation and diabetes.

The Journal of clinical investigation

Jaafar R, Tran S, Shah A, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A

Sweet cognition: The differential effects of glucose consumption on attentional food bias in individuals of lean and obese status.

Physiology & behavior

Mason AE, Jhaveri K, Schleicher S, Almeida C, Hartman A, Wackerly A, Alba D, Koliwad SK, Epel ES, Aschbacher K

Hypothalamic microglia as potential regulators of metabolic physiology.

Nature metabolism

Valdearcos M, Myers MG, Koliwad SK

Fighting obesity by targeting factors regulating beige adipocytes.

Current opinion in clinical nutrition and metabolic care

McQueen AE, Koliwad SK, Wang JC

Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans.

The Journal of clinical endocrinology and metabolism

Alba DL, Farooq JA, Lin MYC, Schafer AL, Shepherd J, Koliwad SK

Progranulin in the hematopoietic compartment protects mice from atherosclerosis.

Atherosclerosis

Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV

Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.

Cell metabolism

Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK

Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.

Endocrinology

Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW

Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice.

British journal of anaesthesia

Hu J, Feng X, Valdearcos M, Lutrin D, Uchida Y, Koliwad SK, Maze M

Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis.

Cell metabolism

Hasegawa Y, Ikeda K, Chen Y, Alba DL, Stifler D, Shinoda K, Hosono T, Maretich P, Yang Y, Ishigaki Y, Chi J, Cohen P, Koliwad SK, Kajimura S

Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.

The Journal of biological chemistry

Gray NE, Lam LN, Yang K, Zhou AY, Koliwad S, Wang JC

The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure.

The Journal of biological chemistry

McQueen AE, Kanamaluru D, Yan K, Gray NE, Wu L, Li ML, Chang A, Hasan A, Stifler D, Koliwad SK, Wang JC

Digital Diabetes Congress 2017.

Journal of diabetes science and technology

Klonoff DC, Kerr D, Wong JC, Pavlovic Y, Koliwad S, Hu J, Salber P, Aguilera A, Long W, Hamilton G, Chen KY, Adi S

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.

Cell metabolism

Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV

Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.

Cell metabolism

Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK

Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.

Cell reports

Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW

Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice.

JCI insight

Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK

GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance.

JCI insight

Kuang R, Jahangiri A, Mascharak S, Nguyen A, Chandra A, Flanigan PM, Yagnik G, Wagner JR, De Lay M, Carrera D, Castro BA, Hayes J, Sidorov M, Garcia JL, Eriksson P, Ronen S, Phillips J, Molinaro A, Koliwad S, Aghi MK

The Electronic CardioMetabolic Program (eCMP) for Patients With Cardiometabolic Risk: A Randomized Controlled Trial.

Journal of medical Internet research

Azar KM, Koliwad S, Poon T, Xiao L, Lv N, Griggs R, Ma J

Saturated Fatty Acids Engage an IRE1a-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells.

Cell reports

Robblee MM, Kim CC, Porter Abate J, Valdearcos M, Sandlund KL, Shenoy MK, Volmer R, Iwawaki T, Koliwad SK

Leptin potentiates astrogenesis in the developing hypothalamus.

Molecular metabolism

Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW

Hypothalamic inflammation in the control of metabolic function.

Annual review of physiology

Valdearcos M, Xu AW, Koliwad SK

Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

Cell reports

Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK

A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.

Hepatology (Baltimore, Md.)

Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H

Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Warne JP, Varonin JM, Nielsen SS, Olofsson LE, Kaelin CB, Chua S, Barsh GS, Koliwad SK, Xu AW

Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.

The Journal of biological chemistry

Gray NE, Lam LN, Yang K, Zhou AY, Koliwad S, Wang JC

Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.

Aging

Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.

The Journal of clinical investigation

Koliwad SK, Streeper RS, Monetti M, Cornelissen I, Chan L, Terayama K, Naylor S, Rao M, Hubbard B, Farese RV

Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.

Journal of lipid research

Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV

Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.

American journal of physiology. Endocrinology and metabolism

Streeper RS, Koliwad SK, Villanueva CJ, Farese RV

Increased longevity in mice lacking DGAT1.

The FASEB Journal

Ryan S Streeper, Sylvaine Cases, Suneil K Koliwad, Robert V Farese

Redox control of ion channel activity in vascular endothelial cells by glutathione.

Microcirculation (New York, N.Y. : 1994)

Elliott SJ, Koliwad SK

Oxidant stress and endothelial membrane transport.

Free radical biology & medicine

Elliott SJ, Koliwad SK